Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease
Objectives. Behçet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of death-domai...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/41783 |
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| author | Ahmet Dursun Hatice Gul Durakbasi-Dursun Ayse Gul Zamani Zerrin Gülin Gulbahar Recep Dursun Cengiz Yakicier |
| author_facet | Ahmet Dursun Hatice Gul Durakbasi-Dursun Ayse Gul Zamani Zerrin Gülin Gulbahar Recep Dursun Cengiz Yakicier |
| author_sort | Ahmet Dursun |
| collection | DOAJ |
| description | Objectives. Behçet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of
death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD. Methods. We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR-analysis and direct sequencing. Results. Neither deletion or insertion mutations nor point mutations in pyrin domain were found in any patient. Conclusion. Although pyrin gene mutations have been reported in patients with BD, pyrin domain is not mutated. However, alterations in other regions of MEFV gene and interaction
between pyrin domains are needed to be further investigated. |
| format | Article |
| id | doaj-art-1a521141283e46a497f3d74f81612f03 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1a521141283e46a497f3d74f81612f032025-02-03T05:51:24ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/4178341783Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's DiseaseAhmet Dursun0Hatice Gul Durakbasi-Dursun1Ayse Gul Zamani2Zerrin Gülin Gulbahar3Recep Dursun4Cengiz Yakicier5Department of Medical Genetics, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Medical Genetics, Meram Medical Faculty, Selcuk University, Konya 42080, TurkeyDepartment of Medical Genetics, Meram Medical Faculty, Selcuk University, Konya 42080, TurkeyDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, TurkeyDepartment of Dermatology, Baskent University, Konya 42080, TurkeyDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, TurkeyObjectives. Behçet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD. Methods. We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR-analysis and direct sequencing. Results. Neither deletion or insertion mutations nor point mutations in pyrin domain were found in any patient. Conclusion. Although pyrin gene mutations have been reported in patients with BD, pyrin domain is not mutated. However, alterations in other regions of MEFV gene and interaction between pyrin domains are needed to be further investigated.http://dx.doi.org/10.1155/MI/2006/41783 |
| spellingShingle | Ahmet Dursun Hatice Gul Durakbasi-Dursun Ayse Gul Zamani Zerrin Gülin Gulbahar Recep Dursun Cengiz Yakicier Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease Mediators of Inflammation |
| title | Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease |
| title_full | Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease |
| title_fullStr | Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease |
| title_full_unstemmed | Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease |
| title_short | Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease |
| title_sort | genetic analysis of mefv gene pyrin domain in patients with behcet s disease |
| url | http://dx.doi.org/10.1155/MI/2006/41783 |
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