MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES
Currently in the Russian Federation or chronic hepatitis C (CHC) are still relevant Interferon-based regimens. The purpose of this study is to investigate the influence of baseline characteristics and prognosis of the patient HCV genotype 1 for the development of leukopenia (LP) and neutropenia (N...
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SINAPS LLC
2016-10-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/571 |
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| author | I. G. Bakulin N. Kh. Dianova Yu. G. Sandler M. Yu. Prostov |
| author_facet | I. G. Bakulin N. Kh. Dianova Yu. G. Sandler M. Yu. Prostov |
| author_sort | I. G. Bakulin |
| collection | DOAJ |
| description | Currently in the Russian Federation or chronic hepatitis C (CHC) are still relevant Interferon-based regimens. The purpose of this study is to investigate the influence of baseline characteristics and prognosis of the patient HCV genotype 1 for the development of leukopenia (LP) and neutropenia (NP). We investigated factors such as sex, age, body mass index (BMI), viral load, genotype of Interleukin-28 B (IL-28B), the initial level of leukocytes and neutrophils, alanine aminotransferase (ALT), fibrosis, duration of infection, presence of previous therapy. Absolute values of leukocytes and neutrophils were analyzed on 4, 12, 24, 48 weeks of therapy, and at 4, 12, 24 weeks after antiviral treatment with protease inhibitors (PI) 1 and 2 generation. Prognostic criteria were identified, indicating the possible development of the LP and NP expressed during treatment with interferon: female gender, low initial load, TT-genotype of IL-28B, the initial level of white blood cells and neutrophils below 5,7×109/L and 3,4×109/L, respectively. Mathematical models predicting the onset of LP and NP, formalized in the form of decision trees were also constructed. These models have shown the greatest potential for practical use in view of highest accuracy and reliability. |
| format | Article |
| id | doaj-art-1a520b402b5c45d982b2dd139d4b0261 |
| institution | Kabale University |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2016-10-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-1a520b402b5c45d982b2dd139d4b02612025-08-20T03:37:57ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642016-10-0165536210.20514/2226-6704-2016-6-5-53-62549MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMESI. G. Bakulin0N. Kh. Dianova1Yu. G. Sandler2M. Yu. Prostov3Moscow Clinical Scientific Center of Moscow Healthcare Department , MoscowMoscow Clinical Scientific Center of Moscow Healthcare Department , MoscowMoscow Clinical Scientific Center of Moscow Healthcare Department , MoscowDistributed Information Systems, Closed Joint Stock Company, MoscowCurrently in the Russian Federation or chronic hepatitis C (CHC) are still relevant Interferon-based regimens. The purpose of this study is to investigate the influence of baseline characteristics and prognosis of the patient HCV genotype 1 for the development of leukopenia (LP) and neutropenia (NP). We investigated factors such as sex, age, body mass index (BMI), viral load, genotype of Interleukin-28 B (IL-28B), the initial level of leukocytes and neutrophils, alanine aminotransferase (ALT), fibrosis, duration of infection, presence of previous therapy. Absolute values of leukocytes and neutrophils were analyzed on 4, 12, 24, 48 weeks of therapy, and at 4, 12, 24 weeks after antiviral treatment with protease inhibitors (PI) 1 and 2 generation. Prognostic criteria were identified, indicating the possible development of the LP and NP expressed during treatment with interferon: female gender, low initial load, TT-genotype of IL-28B, the initial level of white blood cells and neutrophils below 5,7×109/L and 3,4×109/L, respectively. Mathematical models predicting the onset of LP and NP, formalized in the form of decision trees were also constructed. These models have shown the greatest potential for practical use in view of highest accuracy and reliability.https://www.medarhive.ru/jour/article/view/571chronic hepatitis cantiviral therapygenotype 1protease inhibitors 1 and 2 generationinterferon-based regimensadverse eventsleukopenianeutropeniaprognosismathematical modelsdecision trees |
| spellingShingle | I. G. Bakulin N. Kh. Dianova Yu. G. Sandler M. Yu. Prostov MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES Архивъ внутренней медицины chronic hepatitis c antiviral therapy genotype 1 protease inhibitors 1 and 2 generation interferon-based regimens adverse events leukopenia neutropenia prognosis mathematical models decision trees |
| title | MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES |
| title_full | MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES |
| title_fullStr | MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES |
| title_full_unstemmed | MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES |
| title_short | MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES |
| title_sort | mathematical models predicting leukopenia and neutropenia in patients with chronic hepatitis c in the background interferoncontaining schemes |
| topic | chronic hepatitis c antiviral therapy genotype 1 protease inhibitors 1 and 2 generation interferon-based regimens adverse events leukopenia neutropenia prognosis mathematical models decision trees |
| url | https://www.medarhive.ru/jour/article/view/571 |
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