PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response
PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been wid...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/989673 |
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| author | Nuriban Valero-Pacheco Lourdes Arriaga-Pizano Eduardo Ferat-Osorio Luz María Mora-Velandia Rodolfo Pastelin-Palacios Miguel Ángel Villasís-Keever Celia Alpuche-Aranda Luvia Enid Sánchez-Torres Armando Isibasi Laura Bonifaz Constantino López-Macías |
| author_facet | Nuriban Valero-Pacheco Lourdes Arriaga-Pizano Eduardo Ferat-Osorio Luz María Mora-Velandia Rodolfo Pastelin-Palacios Miguel Ángel Villasís-Keever Celia Alpuche-Aranda Luvia Enid Sánchez-Torres Armando Isibasi Laura Bonifaz Constantino López-Macías |
| author_sort | Nuriban Valero-Pacheco |
| collection | DOAJ |
| description | PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8+ T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8+ T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus. |
| format | Article |
| id | doaj-art-1a4da07dcb6a464d85bdd2030e398989 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-1a4da07dcb6a464d85bdd2030e3989892025-08-20T03:54:21ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/989673989673PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell ResponseNuriban Valero-Pacheco0Lourdes Arriaga-Pizano1Eduardo Ferat-Osorio2Luz María Mora-Velandia3Rodolfo Pastelin-Palacios4Miguel Ángel Villasís-Keever5Celia Alpuche-Aranda6Luvia Enid Sánchez-Torres7Armando Isibasi8Laura Bonifaz9Constantino López-Macías10Medical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre “Siglo XXI,” Mexican Social Security Institute (IMSS), 06720 México, DF, MexicoMedical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre “Siglo XXI,” Mexican Social Security Institute (IMSS), 06720 México, DF, MexicoMedical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre “Siglo XXI,” Mexican Social Security Institute (IMSS), 06720 México, DF, MexicoMedical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre “Siglo XXI,” Mexican Social Security Institute (IMSS), 06720 México, DF, MexicoFacultad de Química, Universidad Nacional Autónoma de México, 04510 México, DF, MexicoUnidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), 06720 México, DF, MexicoInstituto Nacional de Salud Pública, 62100 Cuernavaca, MOR, MexicoDepartamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 México, DF, MexicoMedical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre “Siglo XXI,” Mexican Social Security Institute (IMSS), 06720 México, DF, MexicoMedical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre “Siglo XXI,” Mexican Social Security Institute (IMSS), 06720 México, DF, MexicoMedical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre “Siglo XXI,” Mexican Social Security Institute (IMSS), 06720 México, DF, MexicoPD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8+ T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8+ T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.http://dx.doi.org/10.1155/2013/989673 |
| spellingShingle | Nuriban Valero-Pacheco Lourdes Arriaga-Pizano Eduardo Ferat-Osorio Luz María Mora-Velandia Rodolfo Pastelin-Palacios Miguel Ángel Villasís-Keever Celia Alpuche-Aranda Luvia Enid Sánchez-Torres Armando Isibasi Laura Bonifaz Constantino López-Macías PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response Clinical and Developmental Immunology |
| title | PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response |
| title_full | PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response |
| title_fullStr | PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response |
| title_full_unstemmed | PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response |
| title_short | PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response |
| title_sort | pd l1 expression induced by the 2009 pandemic influenza a h1n1 virus impairs the human t cell response |
| url | http://dx.doi.org/10.1155/2013/989673 |
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