Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression
Objective The aim of the present study was to assess the expression of the Ikaros transcription factor (IKZF1) in lung adenocarcinoma and investigate whether expression levels of Ikaros are correlated with lung adenocarcinoma progression. Methods We conducted a retrospective study of 325 cases of re...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-08-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520945860 |
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| _version_ | 1850099526523682816 |
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| author | Wei Zhao Tong-bing Chen Hui Wang |
| author_facet | Wei Zhao Tong-bing Chen Hui Wang |
| author_sort | Wei Zhao |
| collection | DOAJ |
| description | Objective The aim of the present study was to assess the expression of the Ikaros transcription factor (IKZF1) in lung adenocarcinoma and investigate whether expression levels of Ikaros are correlated with lung adenocarcinoma progression. Methods We conducted a retrospective study of 325 cases of resected stage I pulmonary adenocarcinoma, in which histological subtyping was performed according to the 2015 World Health Organization classification. We performed immunohistochemical examinations to assess expression of Ikaros in pulmonary adenocarcinomas and evaluated the correlation between Ikaros expression and cancer progression. Results Immunohistochemical staining was heterogeneous, with the majority of well-differentiated and moderately differentiated lung adenocarcinomas being weakly positive and the majority of the poorly differentiated lung adenocarcinomas exhibiting strong positive staining. Higher expression of Ikaros was associated with tumor recurrence or metastasis. Conclusions Ikaros is heterogeneously expressed in different subtypes of lung adenocarcinoma; higher expression of Ikaros was found to be associated with cancer progression. |
| format | Article |
| id | doaj-art-1a49d3840feb4c3fab9f27fbd1959412 |
| institution | DOAJ |
| issn | 1473-2300 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-1a49d3840feb4c3fab9f27fbd19594122025-08-20T02:40:29ZengSAGE PublishingJournal of International Medical Research1473-23002020-08-014810.1177/0300060520945860Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progressionWei ZhaoTong-bing ChenHui WangObjective The aim of the present study was to assess the expression of the Ikaros transcription factor (IKZF1) in lung adenocarcinoma and investigate whether expression levels of Ikaros are correlated with lung adenocarcinoma progression. Methods We conducted a retrospective study of 325 cases of resected stage I pulmonary adenocarcinoma, in which histological subtyping was performed according to the 2015 World Health Organization classification. We performed immunohistochemical examinations to assess expression of Ikaros in pulmonary adenocarcinomas and evaluated the correlation between Ikaros expression and cancer progression. Results Immunohistochemical staining was heterogeneous, with the majority of well-differentiated and moderately differentiated lung adenocarcinomas being weakly positive and the majority of the poorly differentiated lung adenocarcinomas exhibiting strong positive staining. Higher expression of Ikaros was associated with tumor recurrence or metastasis. Conclusions Ikaros is heterogeneously expressed in different subtypes of lung adenocarcinoma; higher expression of Ikaros was found to be associated with cancer progression.https://doi.org/10.1177/0300060520945860 |
| spellingShingle | Wei Zhao Tong-bing Chen Hui Wang Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression Journal of International Medical Research |
| title | Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression |
| title_full | Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression |
| title_fullStr | Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression |
| title_full_unstemmed | Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression |
| title_short | Ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression |
| title_sort | ikaros is heterogeneously expressed in lung adenocarcinoma and is involved in its progression |
| url | https://doi.org/10.1177/0300060520945860 |
| work_keys_str_mv | AT weizhao ikarosisheterogeneouslyexpressedinlungadenocarcinomaandisinvolvedinitsprogression AT tongbingchen ikarosisheterogeneouslyexpressedinlungadenocarcinomaandisinvolvedinitsprogression AT huiwang ikarosisheterogeneouslyexpressedinlungadenocarcinomaandisinvolvedinitsprogression |