Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients
Abstract Central lymph node metastasis (CLNM) is observed in 20-90% of patients with differentiated thyroid cancer (DTC). Central lymph node dissection (CLND) is associated with a higher incidence of complications, including hypocalcemia and an increased risk of recurrent laryngeal nerve injury. Thi...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-08439-8 |
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| author | Khalid Atallah Shadi Awny Khaled Abdelwahab Ahmed Abdallah Islam H Metwally Omar Hamdy Mohammed Zuhdy Ahmed Fareed |
| author_facet | Khalid Atallah Shadi Awny Khaled Abdelwahab Ahmed Abdallah Islam H Metwally Omar Hamdy Mohammed Zuhdy Ahmed Fareed |
| author_sort | Khalid Atallah |
| collection | DOAJ |
| description | Abstract Central lymph node metastasis (CLNM) is observed in 20-90% of patients with differentiated thyroid cancer (DTC). Central lymph node dissection (CLND) is associated with a higher incidence of complications, including hypocalcemia and an increased risk of recurrent laryngeal nerve injury. This study aimed to characterize and analyze the morbidity of CLND precisely. This is a retrospective cohort study that included patients who were diagnosed with thyroid cancer and underwent total thyroidectomy and CLND at a tertiary cancer center from January 2012 to December 2023. Among 420 patients, intraoperative complications were observed in 47 patients (11.2%). The commonest was recurrent laryngeal nerve palsy, which occurred in 16 patients. Stridor was detected immediately after extubating five patients. The commonest postoperative complication was hypocalcemia, which occurred in 69 patients (16.4% of patients), 21 patients (5%) required hospital re-admission, and most of them were temporary (79.4%). CLND may lead to morbidity in 1 to 2 of every 10 patients. Better diagnostic tools and predictive models are mandatory to identify the central compartment disease burden. Moreover, more advanced surgical techniques are needed to spare the patients the potential complications. |
| format | Article |
| id | doaj-art-1a484c635cf746b09ad1ca0d19cafd6e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-1a484c635cf746b09ad1ca0d19cafd6e2025-08-20T03:45:28ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-08439-8Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patientsKhalid Atallah0Shadi Awny1Khaled Abdelwahab2Ahmed Abdallah3Islam H Metwally4Omar Hamdy5Mohammed Zuhdy6Ahmed Fareed7Surgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversitySurgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversitySurgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversitySurgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversitySurgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversitySurgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversitySurgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversitySurgical Oncology Department, Oncology Center, Faculty of Medicine, Mansoura UniversityAbstract Central lymph node metastasis (CLNM) is observed in 20-90% of patients with differentiated thyroid cancer (DTC). Central lymph node dissection (CLND) is associated with a higher incidence of complications, including hypocalcemia and an increased risk of recurrent laryngeal nerve injury. This study aimed to characterize and analyze the morbidity of CLND precisely. This is a retrospective cohort study that included patients who were diagnosed with thyroid cancer and underwent total thyroidectomy and CLND at a tertiary cancer center from January 2012 to December 2023. Among 420 patients, intraoperative complications were observed in 47 patients (11.2%). The commonest was recurrent laryngeal nerve palsy, which occurred in 16 patients. Stridor was detected immediately after extubating five patients. The commonest postoperative complication was hypocalcemia, which occurred in 69 patients (16.4% of patients), 21 patients (5%) required hospital re-admission, and most of them were temporary (79.4%). CLND may lead to morbidity in 1 to 2 of every 10 patients. Better diagnostic tools and predictive models are mandatory to identify the central compartment disease burden. Moreover, more advanced surgical techniques are needed to spare the patients the potential complications.https://doi.org/10.1038/s41598-025-08439-8Papillary thyroid carcinomaMedullary thyroid carcinomaThyroid cancerCentral lymph node dissectionHypocalcemiaRecurrent laryngeal nerve injury |
| spellingShingle | Khalid Atallah Shadi Awny Khaled Abdelwahab Ahmed Abdallah Islam H Metwally Omar Hamdy Mohammed Zuhdy Ahmed Fareed Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients Scientific Reports Papillary thyroid carcinoma Medullary thyroid carcinoma Thyroid cancer Central lymph node dissection Hypocalcemia Recurrent laryngeal nerve injury |
| title | Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients |
| title_full | Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients |
| title_fullStr | Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients |
| title_full_unstemmed | Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients |
| title_short | Morbidity patterns and long-term outcomes of central lymph node dissection in thyroid cancer patients |
| title_sort | morbidity patterns and long term outcomes of central lymph node dissection in thyroid cancer patients |
| topic | Papillary thyroid carcinoma Medullary thyroid carcinoma Thyroid cancer Central lymph node dissection Hypocalcemia Recurrent laryngeal nerve injury |
| url | https://doi.org/10.1038/s41598-025-08439-8 |
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