Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment
Metabolic reprogramming is one of the major biological features of malignant tumors, playing a crucial role in the initiation and progression of cancer. The tumor microenvironment consists of various non-cancer cells, such as hepatic stellate cells, cancer-associated fibroblasts (CAFs), immune cells...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1494788/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849721601546780672 |
|---|---|
| author | Haoqiang Yang Jinghui Li Yiting Niu Tao Zhou Pengyu Zhang Yang Liu Yanjun Li Yanjun Li |
| author_facet | Haoqiang Yang Jinghui Li Yiting Niu Tao Zhou Pengyu Zhang Yang Liu Yanjun Li Yanjun Li |
| author_sort | Haoqiang Yang |
| collection | DOAJ |
| description | Metabolic reprogramming is one of the major biological features of malignant tumors, playing a crucial role in the initiation and progression of cancer. The tumor microenvironment consists of various non-cancer cells, such as hepatic stellate cells, cancer-associated fibroblasts (CAFs), immune cells, as well as extracellular matrix and soluble substances. In liver cancer, metabolic reprogramming not only affects its own growth and survival but also interacts with other non-cancer cells by influencing the expression and release of metabolites and cytokines (such as lactate, PGE2, arginine). This interaction leads to acidification of the microenvironment and restricts the uptake of nutrients by other non-cancer cells, resulting in metabolic competition and symbiosis. At the same time, metabolic reprogramming in neighboring cells during proliferation and differentiation processes also impacts tumor immunity. This article provides a comprehensive overview of the metabolic crosstalk between liver cancer cells and their tumor microenvironment, deepening our understanding of relevant findings and pathways. This contributes to further understanding the regulation of cancer development and immune evasion mechanisms while providing assistance in advancing personalized therapies targeting metabolic pathways for anti-cancer treatment. |
| format | Article |
| id | doaj-art-1a46533ecc2143a0851bb3367426a08a |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1a46533ecc2143a0851bb3367426a08a2025-08-20T03:11:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.14947881494788Interactions between the metabolic reprogramming of liver cancer and tumor microenvironmentHaoqiang Yang0Jinghui Li1Yiting Niu2Tao Zhou3Pengyu Zhang4Yang Liu5Yanjun Li6Yanjun Li7Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, TongjiShanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaMetabolic reprogramming is one of the major biological features of malignant tumors, playing a crucial role in the initiation and progression of cancer. The tumor microenvironment consists of various non-cancer cells, such as hepatic stellate cells, cancer-associated fibroblasts (CAFs), immune cells, as well as extracellular matrix and soluble substances. In liver cancer, metabolic reprogramming not only affects its own growth and survival but also interacts with other non-cancer cells by influencing the expression and release of metabolites and cytokines (such as lactate, PGE2, arginine). This interaction leads to acidification of the microenvironment and restricts the uptake of nutrients by other non-cancer cells, resulting in metabolic competition and symbiosis. At the same time, metabolic reprogramming in neighboring cells during proliferation and differentiation processes also impacts tumor immunity. This article provides a comprehensive overview of the metabolic crosstalk between liver cancer cells and their tumor microenvironment, deepening our understanding of relevant findings and pathways. This contributes to further understanding the regulation of cancer development and immune evasion mechanisms while providing assistance in advancing personalized therapies targeting metabolic pathways for anti-cancer treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1494788/fullhepatocellular carcinomatumor microenvironmentmetabolism reprogramsignaling pathwaysimmune evasion |
| spellingShingle | Haoqiang Yang Jinghui Li Yiting Niu Tao Zhou Pengyu Zhang Yang Liu Yanjun Li Yanjun Li Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment Frontiers in Immunology hepatocellular carcinoma tumor microenvironment metabolism reprogram signaling pathways immune evasion |
| title | Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment |
| title_full | Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment |
| title_fullStr | Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment |
| title_full_unstemmed | Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment |
| title_short | Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment |
| title_sort | interactions between the metabolic reprogramming of liver cancer and tumor microenvironment |
| topic | hepatocellular carcinoma tumor microenvironment metabolism reprogram signaling pathways immune evasion |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1494788/full |
| work_keys_str_mv | AT haoqiangyang interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment AT jinghuili interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment AT yitingniu interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment AT taozhou interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment AT pengyuzhang interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment AT yangliu interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment AT yanjunli interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment AT yanjunli interactionsbetweenthemetabolicreprogrammingoflivercancerandtumormicroenvironment |