Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study
Nowadays, inflammatory bowel disease (IBD)-patient therapies are mainly based on corticosteroid, thiopurine, and immunomodulator treatments. Patients with active disease, that do not respond to corticosteroid and/or thiopurine treatment, can switch to the usage of the chimeric monoclonal antibody in...
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250036 |
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| author | Mirco Vacca Eduardo Maria Sommella Marina Liso Giulio Verna Aurelia Scarano Annamaria Sila Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Bruno Di Jeso Angelo Santino Vincenzo Vestuto Fabrizio Merciai Gianluigi Giannelli Pietro Campiglia Maria De Angelis Marcello Chieppa Francesco Maria Calabrese |
| author_facet | Mirco Vacca Eduardo Maria Sommella Marina Liso Giulio Verna Aurelia Scarano Annamaria Sila Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Bruno Di Jeso Angelo Santino Vincenzo Vestuto Fabrizio Merciai Gianluigi Giannelli Pietro Campiglia Maria De Angelis Marcello Chieppa Francesco Maria Calabrese |
| author_sort | Mirco Vacca |
| collection | DOAJ |
| description | Nowadays, inflammatory bowel disease (IBD)-patient therapies are mainly based on corticosteroid, thiopurine, and immunomodulator treatments. Patients with active disease, that do not respond to corticosteroid and/or thiopurine treatment, can switch to the usage of the chimeric monoclonal antibody infliximab (IFX). However, to date, no treatment appeared to be conclusive in lowering the incidence of IBD relapses. With the aim to increase the effectiveness of IFX treatment, we combined it with an adjuvant purple corn supplementation enriched in anthocyanins. IBD-patients were enrolled before they underwent to the IFX-infusion, and they were allocated in 2 different study arms. Patients in the intervention-arm followed a dietary supplementation with purple corn water-soluble extract, whereas control patients had a daily consumption of red fruit tea. 16S rDNA gene-sequencing and high-resolution mass-spectrometry metabo-lipidomics analyses were conducted on stool and sera samples, respectively. As a result, the experimental intervention mainly affected the serum metabolome of IBD-patients by decreasing the concentration of specific lipids. Focusing on IBD patient annotated taxa, a significant decrease in Lactobacillus and Bifidobacterium relative abundances was found. As far as it concerns the ulcerative colitis patient subset, the experimental intervention led to a decrease in Alistipes and Erysipelotrichaceae UCG-003 genus abundances and a concomitant Parabacteroides increase. On the contrary, after treatment, Crohn’s disease patients did not exhibit metataxonomics differences at the genus level. At the end of the treatment that led to a reshaped microbiota community, the gathered data paves the way for the usage of a specifically designed probiotic supplementation as a valuable strategy for IBD-patients under IFX infusion. |
| format | Article |
| id | doaj-art-1a451705e14943bcac654a27bc915c30 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-1a451705e14943bcac654a27bc915c302025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363536354310.26599/FSHW.2023.9250036Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot studyMirco Vacca0Eduardo Maria Sommella1Marina Liso2Giulio Verna3Aurelia Scarano4Annamaria Sila5Margherita Curlo6Mauro Mastronardi7Katia Petroni8Chiara Tonelli9Bruno Di Jeso10Angelo Santino11Vincenzo Vestuto12Fabrizio Merciai13Gianluigi Giannelli14Pietro Campiglia15Maria De Angelis16Marcello Chieppa17Francesco Maria Calabrese18Department of Soil, Plant and Food Science, University of Bari Aldo Moro, Bari 70126, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, Fisciano 84084, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “S. de Bellis”, Castellana Grotte 70013, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, Fisciano 84084, ItalyUnit of Lecce, Institute of Sciences of Food Production C.N.R., Lecce 73100, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “S. de Bellis”, Castellana Grotte 70013, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “S. de Bellis”, Castellana Grotte 70013, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “S. de Bellis”, Castellana Grotte 70013, ItalyDepartment of Biosciences, University of Milan, Milan 20133, ItalyDepartment of Biosciences, University of Milan, Milan 20133, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, Lecce 73100, ItalyUnit of Lecce, Institute of Sciences of Food Production C.N.R., Lecce 73100, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, Fisciano 84084, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, Fisciano 84084, ItalyFunctional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS “S. de Bellis”, Castellana Grotte 70013, ItalyDepartment of Pharmacy, School of Pharmacy, University of Salerno, Fisciano 84084, ItalyDepartment of Soil, Plant and Food Science, University of Bari Aldo Moro, Bari 70126, ItalyDepartment of Biological and Environmental Sciences and Technologies (DISTEBA), University of Salento, Lecce 73100, ItalyDepartment of Soil, Plant and Food Science, University of Bari Aldo Moro, Bari 70126, ItalyNowadays, inflammatory bowel disease (IBD)-patient therapies are mainly based on corticosteroid, thiopurine, and immunomodulator treatments. Patients with active disease, that do not respond to corticosteroid and/or thiopurine treatment, can switch to the usage of the chimeric monoclonal antibody infliximab (IFX). However, to date, no treatment appeared to be conclusive in lowering the incidence of IBD relapses. With the aim to increase the effectiveness of IFX treatment, we combined it with an adjuvant purple corn supplementation enriched in anthocyanins. IBD-patients were enrolled before they underwent to the IFX-infusion, and they were allocated in 2 different study arms. Patients in the intervention-arm followed a dietary supplementation with purple corn water-soluble extract, whereas control patients had a daily consumption of red fruit tea. 16S rDNA gene-sequencing and high-resolution mass-spectrometry metabo-lipidomics analyses were conducted on stool and sera samples, respectively. As a result, the experimental intervention mainly affected the serum metabolome of IBD-patients by decreasing the concentration of specific lipids. Focusing on IBD patient annotated taxa, a significant decrease in Lactobacillus and Bifidobacterium relative abundances was found. As far as it concerns the ulcerative colitis patient subset, the experimental intervention led to a decrease in Alistipes and Erysipelotrichaceae UCG-003 genus abundances and a concomitant Parabacteroides increase. On the contrary, after treatment, Crohn’s disease patients did not exhibit metataxonomics differences at the genus level. At the end of the treatment that led to a reshaped microbiota community, the gathered data paves the way for the usage of a specifically designed probiotic supplementation as a valuable strategy for IBD-patients under IFX infusion.https://www.sciopen.com/article/10.26599/FSHW.2023.9250036inflammatory bowel diseaseinfliximab infusionantioxidantsnutrigenomicsadjuvant therapy |
| spellingShingle | Mirco Vacca Eduardo Maria Sommella Marina Liso Giulio Verna Aurelia Scarano Annamaria Sila Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Bruno Di Jeso Angelo Santino Vincenzo Vestuto Fabrizio Merciai Gianluigi Giannelli Pietro Campiglia Maria De Angelis Marcello Chieppa Francesco Maria Calabrese Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study Food Science and Human Wellness inflammatory bowel disease infliximab infusion antioxidants nutrigenomics adjuvant therapy |
| title | Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study |
| title_full | Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study |
| title_fullStr | Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study |
| title_full_unstemmed | Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study |
| title_short | Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study |
| title_sort | anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion the sicura pilot study |
| topic | inflammatory bowel disease infliximab infusion antioxidants nutrigenomics adjuvant therapy |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250036 |
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