Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade
PD-1 blockade is now routine for nearly all patients with non-small lung cancer. Acquired resistance to PD-1 blockade – defined generally as an initial response followed later by progression [1-3] is a common yet poorly understood concept. A key clinical challenge to insight has been a lack of stand...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Future Science OA |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0010 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850099356182511616 |
|---|---|
| author | Dilanka Lakshan De Silva Jia Luo |
| author_facet | Dilanka Lakshan De Silva Jia Luo |
| author_sort | Dilanka Lakshan De Silva |
| collection | DOAJ |
| description | PD-1 blockade is now routine for nearly all patients with non-small lung cancer. Acquired resistance to PD-1 blockade – defined generally as an initial response followed later by progression [1-3] is a common yet poorly understood concept. A key clinical challenge to insight has been a lack of standard guidance for clinical management of a case of suspected acquired resistance. The infrequency of performing tumor biopsies and the uncertainty of actionability from tissue sampling likely also contribute to limited insight into the biology of acquired resistance [4]. To address this knowledge gap and to highlight the value of tumor and liquid biopsy, we present a representative case of suspected acquired resistance to PD-1 blockade and propose a multi-modal guide for approaching this clinical scenario. |
| format | Article |
| id | doaj-art-1a44020dc2ec4e12a1f8014ca6cde02c |
| institution | DOAJ |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-1a44020dc2ec4e12a1f8014ca6cde02c2025-08-20T02:40:30ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.2144/fsoa-2023-0010Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockadeDilanka Lakshan De Silva0Jia Luo1Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USAThoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USAPD-1 blockade is now routine for nearly all patients with non-small lung cancer. Acquired resistance to PD-1 blockade – defined generally as an initial response followed later by progression [1-3] is a common yet poorly understood concept. A key clinical challenge to insight has been a lack of standard guidance for clinical management of a case of suspected acquired resistance. The infrequency of performing tumor biopsies and the uncertainty of actionability from tissue sampling likely also contribute to limited insight into the biology of acquired resistance [4]. To address this knowledge gap and to highlight the value of tumor and liquid biopsy, we present a representative case of suspected acquired resistance to PD-1 blockade and propose a multi-modal guide for approaching this clinical scenario.https://www.tandfonline.com/doi/10.2144/fsoa-2023-0010acquired resistance to immunotherapyliquid biopsymolecular sequencingnon-small cell lung cancerPD-1 blockadepersonalized medicine |
| spellingShingle | Dilanka Lakshan De Silva Jia Luo Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade Future Science OA acquired resistance to immunotherapy liquid biopsy molecular sequencing non-small cell lung cancer PD-1 blockade personalized medicine |
| title | Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade |
| title_full | Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade |
| title_fullStr | Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade |
| title_full_unstemmed | Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade |
| title_short | Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade |
| title_sort | clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to pd 1 blockade |
| topic | acquired resistance to immunotherapy liquid biopsy molecular sequencing non-small cell lung cancer PD-1 blockade personalized medicine |
| url | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0010 |
| work_keys_str_mv | AT dilankalakshandesilva clinicalapproachandutilizingliquidbiopsiestointerrogatesuspectedacquiredresistancetopd1blockade AT jialuo clinicalapproachandutilizingliquidbiopsiestointerrogatesuspectedacquiredresistancetopd1blockade |