Characteristics of TPT initiation and completion among people living with HIV
BACKGROUND: TB preventive treatment (TPT) reduces morbidity and mortality among people living with HIV (PLHIV). Despite the successful scale-up of TPT in Malawi, monitoring and evaluation have been suboptimal. We utilized the Malawi Population-Based HIV Impact Assessment (MPHIA) 2020–2021 survey dat...
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-01-01
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| Series: | IJTLD Open |
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| author | L. Gunde A. Wang D. Payne S. O'Connor A. Kabaghe N. Kalata A. Maida D. Kayira V. Buie L. Tauzi A. Sankhani A. Thawani E. Rambiki A. Ahimbisibwe T. Maphosa K. Kudiabor R. Nyirenda J. Mpunga K. Mbendera P. Nyasulu F. Kayigamba M. Farahani A. C. Voetsch K. Brown A. Jahn B. Girma K. Mirkovic the MPHIA Survey Team |
| author_facet | L. Gunde A. Wang D. Payne S. O'Connor A. Kabaghe N. Kalata A. Maida D. Kayira V. Buie L. Tauzi A. Sankhani A. Thawani E. Rambiki A. Ahimbisibwe T. Maphosa K. Kudiabor R. Nyirenda J. Mpunga K. Mbendera P. Nyasulu F. Kayigamba M. Farahani A. C. Voetsch K. Brown A. Jahn B. Girma K. Mirkovic the MPHIA Survey Team |
| author_sort | L. Gunde |
| collection | DOAJ |
| description | BACKGROUND: TB preventive treatment (TPT) reduces morbidity and mortality among people living with HIV (PLHIV). Despite the successful scale-up of TPT in Malawi, monitoring and evaluation have been suboptimal. We utilized the Malawi Population-Based HIV Impact Assessment (MPHIA) 2020–2021 survey data to estimate TPT uptake and completion among self-reported HIV-positive persons. METHODS: We estimated the proportion of HIV-positive respondents who had ever undergone TPT, and determined the percentage of those currently on TPT who had completed more than 6 months of treatment. Bivariate and multivariable logistic regression were performed to calculate the odds ratios for factors associated with ever-taking TPT. All variables were self-reported, and the analysis was weighted and accounted for in the survey design. RESULTS: Of the HIV+ respondents, 38.8% (95% CI 36.4–41.3) had ever taken TPT. The adjusted odds of ever taking TPT were 8.0 and 5.2 times as high in the Central and Southern regions, respectively, compared to the Northern region; 1.9 times higher among those in the highest wealth quintile, and 2.1 times higher for those on antiretroviral therapy >10 years. Of those currently taking TPT, 56.2% completed >6 months of TPT. CONCLUSIONS: These results suggest low TPT uptake and >6 months’ completion rates among self-reported HIV+ persons. Initiatives to create demand and strengthen adherence would improve TPT uptake. |
| format | Article |
| id | doaj-art-1a40405a09974707bbbe75c6fde1bde8 |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-1a40405a09974707bbbe75c6fde1bde82025-01-21T09:59:34ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-01-0111111910.5588/ijtldopen.23.01944Characteristics of TPT initiation and completion among people living with HIVL. Gunde0A. Wang1D. Payne2S. O'Connor3A. Kabaghe4N. Kalata5A. Maida6D. Kayira7V. Buie8L. Tauzi9A. Sankhani10A. Thawani11E. Rambiki12A. Ahimbisibwe13T. Maphosa14K. Kudiabor15R. Nyirenda16J. Mpunga17K. Mbendera18P. Nyasulu19F. Kayigamba20M. Farahani21A. C. Voetsch22K. Brown23A. Jahn24B. Girma25K. Mirkovic26the MPHIA Survey TeamU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiU.S. CDC, Atlanta, USAU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiLighthouse Trust, LilongweLighthouse Trust, LilongweLighthouse Trust, LilongweLighthouse Trust, LilongweElizabeth Glaser Pediatric AIDS Foundation (EGPAF), LilongweElizabeth Glaser Pediatric AIDS Foundation (EGPAF), LilongweElizabeth Glaser Pediatric AIDS Foundation (EGPAF), LilongweDepartment of HIV/AIDS, STI and Viral Hepatitis, Ministry of Health, LilongweNational TB and Leprosy Elimination Program, Ministry of Health, Lilongwe, MalawiNational TB and Leprosy Elimination Program, Ministry of Health, Lilongwe, MalawiDepartment of HIV/AIDS, STI and Viral Hepatitis, Ministry of Health, LilongweICAP Global Health, Lilongwe, MalawiICAP at Columbia University, New York, USAU.S. CDC, Atlanta, USAU.S. CDC, Atlanta, USADepartment of HIV/AIDS, STI and Viral Hepatitis, Ministry of Health, LilongweNational TB and Leprosy Elimination Program, Ministry of Health, Lilongwe, MalawiU.S. Centers for Disease Control and Prevention (CDC), Lilongwe, MalawiBACKGROUND: TB preventive treatment (TPT) reduces morbidity and mortality among people living with HIV (PLHIV). Despite the successful scale-up of TPT in Malawi, monitoring and evaluation have been suboptimal. We utilized the Malawi Population-Based HIV Impact Assessment (MPHIA) 2020–2021 survey data to estimate TPT uptake and completion among self-reported HIV-positive persons. METHODS: We estimated the proportion of HIV-positive respondents who had ever undergone TPT, and determined the percentage of those currently on TPT who had completed more than 6 months of treatment. Bivariate and multivariable logistic regression were performed to calculate the odds ratios for factors associated with ever-taking TPT. All variables were self-reported, and the analysis was weighted and accounted for in the survey design. RESULTS: Of the HIV+ respondents, 38.8% (95% CI 36.4–41.3) had ever taken TPT. The adjusted odds of ever taking TPT were 8.0 and 5.2 times as high in the Central and Southern regions, respectively, compared to the Northern region; 1.9 times higher among those in the highest wealth quintile, and 2.1 times higher for those on antiretroviral therapy >10 years. Of those currently taking TPT, 56.2% completed >6 months of TPT. CONCLUSIONS: These results suggest low TPT uptake and >6 months’ completion rates among self-reported HIV+ persons. Initiatives to create demand and strengthen adherence would improve TPT uptake.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00004tuberculosisepidemiologyprevention |
| spellingShingle | L. Gunde A. Wang D. Payne S. O'Connor A. Kabaghe N. Kalata A. Maida D. Kayira V. Buie L. Tauzi A. Sankhani A. Thawani E. Rambiki A. Ahimbisibwe T. Maphosa K. Kudiabor R. Nyirenda J. Mpunga K. Mbendera P. Nyasulu F. Kayigamba M. Farahani A. C. Voetsch K. Brown A. Jahn B. Girma K. Mirkovic the MPHIA Survey Team Characteristics of TPT initiation and completion among people living with HIV IJTLD Open tuberculosis epidemiology prevention |
| title | Characteristics of TPT initiation and completion among people living with HIV |
| title_full | Characteristics of TPT initiation and completion among people living with HIV |
| title_fullStr | Characteristics of TPT initiation and completion among people living with HIV |
| title_full_unstemmed | Characteristics of TPT initiation and completion among people living with HIV |
| title_short | Characteristics of TPT initiation and completion among people living with HIV |
| title_sort | characteristics of tpt initiation and completion among people living with hiv |
| topic | tuberculosis epidemiology prevention |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00004 |
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