Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases
Abstract Background Radiation-induced meningiomas represent a late side effect of cranial radiation therapy. The most widely used diagnostic criteria, despite the lack of a standard description, is a meningioma that develops in a previously irradiated area following a predetermined time interval. Ca...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-02-01
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| Series: | Egyptian Journal of Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41984-025-00373-1 |
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| author | Larisa Andrada Ay Erkin Ozgiray Nevhis Akintürk Emine Serra Kamer Yeşim Ertan |
| author_facet | Larisa Andrada Ay Erkin Ozgiray Nevhis Akintürk Emine Serra Kamer Yeşim Ertan |
| author_sort | Larisa Andrada Ay |
| collection | DOAJ |
| description | Abstract Background Radiation-induced meningiomas represent a late side effect of cranial radiation therapy. The most widely used diagnostic criteria, despite the lack of a standard description, is a meningioma that develops in a previously irradiated area following a predetermined time interval. Case presentation We present four cases of late-onset cranial atypical meningiomas following childhood cranial radiotherapy. Four patients (two females and two males) between 4 and 13 years of age at the time of cranial irradiation developed secondary intracranial meningioma after a latency period of 8–34 years. Surgical resection of the tumors was performed, and histopathological examination revealed a diagnosis of atypical meningioma in all four patients. Conclusion Radiation-induced tumors continue to be a significant side effect of radiotherapy and radiosurgery, and they are frequently identified as recurrent, numerous, and more aggressive. Prolonged follow-up should definitely not be ignored in patients with antecedents of radiotherapy for a primary cerebral tumor or cranial irradiation for an early age malignancy. |
| format | Article |
| id | doaj-art-1a3f81b0c5434f9aa5cdfd4e36ad3b1a |
| institution | Kabale University |
| issn | 2520-8225 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Neurosurgery |
| spelling | doaj-art-1a3f81b0c5434f9aa5cdfd4e36ad3b1a2025-02-09T12:25:17ZengSpringerOpenEgyptian Journal of Neurosurgery2520-82252025-02-014011810.1186/s41984-025-00373-1Radiation-induced meningiomas following childhood cranial radiotherapy—report of four casesLarisa Andrada Ay0Erkin Ozgiray1Nevhis Akintürk2Emine Serra Kamer3Yeşim Ertan4Department of Neurosurgery, Söke Fehime Faik Kocagöz State HospitalDepartment of Neurosurgery, Faculty of Medicine, Ege UniversityDepartment of Neurosurgery, Faculty of Medicine, Ege UniversityDepartment of Radiation Oncology, Faculty of Medicine, Ege UniversityDepartment of Pathology, Faculty of Medicine, Ege UniversityAbstract Background Radiation-induced meningiomas represent a late side effect of cranial radiation therapy. The most widely used diagnostic criteria, despite the lack of a standard description, is a meningioma that develops in a previously irradiated area following a predetermined time interval. Case presentation We present four cases of late-onset cranial atypical meningiomas following childhood cranial radiotherapy. Four patients (two females and two males) between 4 and 13 years of age at the time of cranial irradiation developed secondary intracranial meningioma after a latency period of 8–34 years. Surgical resection of the tumors was performed, and histopathological examination revealed a diagnosis of atypical meningioma in all four patients. Conclusion Radiation-induced tumors continue to be a significant side effect of radiotherapy and radiosurgery, and they are frequently identified as recurrent, numerous, and more aggressive. Prolonged follow-up should definitely not be ignored in patients with antecedents of radiotherapy for a primary cerebral tumor or cranial irradiation for an early age malignancy.https://doi.org/10.1186/s41984-025-00373-1Radiation-induced meningiomaCranial radiotherapyChildhood leukemiaRadiationCase report |
| spellingShingle | Larisa Andrada Ay Erkin Ozgiray Nevhis Akintürk Emine Serra Kamer Yeşim Ertan Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases Egyptian Journal of Neurosurgery Radiation-induced meningioma Cranial radiotherapy Childhood leukemia Radiation Case report |
| title | Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases |
| title_full | Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases |
| title_fullStr | Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases |
| title_full_unstemmed | Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases |
| title_short | Radiation-induced meningiomas following childhood cranial radiotherapy—report of four cases |
| title_sort | radiation induced meningiomas following childhood cranial radiotherapy report of four cases |
| topic | Radiation-induced meningioma Cranial radiotherapy Childhood leukemia Radiation Case report |
| url | https://doi.org/10.1186/s41984-025-00373-1 |
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