Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk.

Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk.

<h4>Background</h4>A promoter polymorphism in the pro-inflammatory cytokine tumor necrosis factor (TNF) (TNF G-308A) is associated with increased non-Hodgkin lymphoma (NHL) risk. The protein product, TNF-alpha, activates the nuclear factor kappa beta (NF-kappaB) transcription factor, and...

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Main Authors: Sophia S Wang, Mark P Purdue, James R Cerhan, Tongzhang Zheng, Idan Menashe, Bruce K Armstrong, Qing Lan, Patricia Hartge, Anne Kricker, Yawei Zhang, Lindsay M Morton, Claire M Vajdic, Theodore R Holford, Richard K Severson, Andrew Grulich, Brian P Leaderer, Scott Davis, Wendy Cozen, Meredith Yeager, Stephen J Chanock, Nilanjan Chatterjee, Nathaniel Rothman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005360&type=printable
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