Odontogenic differentiation of dental pulp stem cells by glycogen synthase kinase-3β inhibitory peptides

Odontogenic differentiation of dental pulp stem cells by glycogen synthase kinase-3β inhibitory peptides

Abstract Background To investigate the effects of peptide-based substrate competitive inhibitors of GSK-3β (GSK-3βi) on promoting odontogenic differentiation of human dental pulp stem cells (hDPSCs). Methods The biocompatibility and proliferation of hDPSCs treated with GSK-3βi peptides (pS9, LRP 6a,...

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Bibliographic Details
Main Authors: Vidhyashree Rajasekar, Mohamed Mahmoud Abdalla, Mohammed S. Basbrain, Prasanna Neelakantan, Cynthia KY Yiu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Dental pulp stem cells
GSK inhibitors
Wnt signaling
Peptides
Online Access:https://doi.org/10.1186/s13287-025-04150-7
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