Renal function affects the plasma concentration and hematological toxicity of linezolid in elderly patients: a propensity-matched cohort analysis

Renal function affects the plasma concentration and hematological toxicity of linezolid in elderly patients: a propensity-matched cohort analysis

Abstract Background The relationships of renal function with linezolid trough concentration (Cmin) and hematological toxicity have not been clarified in elderly patients. Methods In this propensity-matched cohort analysis, elderly patients receiving linezolid at four tertiary hospitals in Beijing be...

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Main Authors: Bing Liu, Guangrui Geng, Tingting Liu, Lingli Zhou, Fang Wang, Ping Yang, Jiaxin Liu, Junshuai Zhao, Cheng Zhao, Yue Wang, Minna Yang, Jing Fu, Jingyue Chen, Xiaomin Chen, Xiangqun Fang, Lixin Xie, Hongxia Li
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Geriatrics
Subjects:
Linezolid
Elderly patients
Renal function
Trough concentration
Hematological toxicity
Online Access:https://doi.org/10.1186/s12877-025-06241-9
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