Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review.
<h4>Introduction</h4>Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. Preclinical studies of nicotine exposure to pregnant mammals could indicate how nicotine may adversely affect the developing fetus. As a first step towards summarising thi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280805&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540023697702912 |
|---|---|
| author | Lucy Phillips Ross Thomson Tom Coleman-Haynes Sue Cooper Felix Naughton Lisa Mcdaid Joanne Emery Tim Coleman |
| author_facet | Lucy Phillips Ross Thomson Tom Coleman-Haynes Sue Cooper Felix Naughton Lisa Mcdaid Joanne Emery Tim Coleman |
| author_sort | Lucy Phillips |
| collection | DOAJ |
| description | <h4>Introduction</h4>Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. Preclinical studies of nicotine exposure to pregnant mammals could indicate how nicotine may adversely affect the developing fetus. As a first step towards summarising this literature, we undertook a systematic scoping review to determine the number and nature of offspring outcomes studied.<h4>Methods</h4>We searched MEDLINE and EMBASE databases for papers reporting empirical data on offspring outcomes following nicotine exposure to pregnant non-human mammals. We excluded studies that investigated exposure to only smoking, e-cigarettes, nicotine vaccines, or studies with no 'nicotine only' group. We developed a draft taxonomy and using this, described and quantified outcomes reported.<h4>Results</h4>We identified 476 studies, which reported 729 offspring outcomes. The draft taxonomy classified outcomes as being measured in i) whole animals, ii) body systems and iii) 'other'. Body system outcomes were further categorised as being functional changes, or changes at macroscopic or cellular levels. The most frequently used outcomes were those detecting changes in the brain (n = 265), physical parameters measured in whole animals (n = 122) and any respiratory system changes (n = 97).<h4>Conclusions</h4>This scoping review quantifies the nature and frequency of outcomes used in preclinical studies investigating the potential impacts of nicotine administration in pregnancy on offspring. Systematic reviews of studies investigating outcomes involving animal brains, respiratory system, or 'whole animal' outcomes may have greatest potential for further advancing knowledge regarding impacts of gestational nicotine exposure on offspring.<h4>Protocol and registration</h4>Protocol for this review can be found on Open Science Framework (https://osf.io/ptmzc/). |
| format | Article |
| id | doaj-art-1a343fff51b34387bacbb4f1f9c80cc9 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-1a343fff51b34387bacbb4f1f9c80cc92025-02-05T05:32:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182e028080510.1371/journal.pone.0280805Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review.Lucy PhillipsRoss ThomsonTom Coleman-HaynesSue CooperFelix NaughtonLisa McdaidJoanne EmeryTim Coleman<h4>Introduction</h4>Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. Preclinical studies of nicotine exposure to pregnant mammals could indicate how nicotine may adversely affect the developing fetus. As a first step towards summarising this literature, we undertook a systematic scoping review to determine the number and nature of offspring outcomes studied.<h4>Methods</h4>We searched MEDLINE and EMBASE databases for papers reporting empirical data on offspring outcomes following nicotine exposure to pregnant non-human mammals. We excluded studies that investigated exposure to only smoking, e-cigarettes, nicotine vaccines, or studies with no 'nicotine only' group. We developed a draft taxonomy and using this, described and quantified outcomes reported.<h4>Results</h4>We identified 476 studies, which reported 729 offspring outcomes. The draft taxonomy classified outcomes as being measured in i) whole animals, ii) body systems and iii) 'other'. Body system outcomes were further categorised as being functional changes, or changes at macroscopic or cellular levels. The most frequently used outcomes were those detecting changes in the brain (n = 265), physical parameters measured in whole animals (n = 122) and any respiratory system changes (n = 97).<h4>Conclusions</h4>This scoping review quantifies the nature and frequency of outcomes used in preclinical studies investigating the potential impacts of nicotine administration in pregnancy on offspring. Systematic reviews of studies investigating outcomes involving animal brains, respiratory system, or 'whole animal' outcomes may have greatest potential for further advancing knowledge regarding impacts of gestational nicotine exposure on offspring.<h4>Protocol and registration</h4>Protocol for this review can be found on Open Science Framework (https://osf.io/ptmzc/).https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280805&type=printable |
| spellingShingle | Lucy Phillips Ross Thomson Tom Coleman-Haynes Sue Cooper Felix Naughton Lisa Mcdaid Joanne Emery Tim Coleman Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. PLoS ONE |
| title | Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. |
| title_full | Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. |
| title_fullStr | Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. |
| title_full_unstemmed | Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. |
| title_short | Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. |
| title_sort | developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals exposure to non tobacco nicotine a systematic scoping review |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280805&type=printable |
| work_keys_str_mv | AT lucyphillips developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview AT rossthomson developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview AT tomcolemanhaynes developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview AT suecooper developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview AT felixnaughton developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview AT lisamcdaid developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview AT joanneemery developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview AT timcoleman developingataxonomytodescribeoffspringoutcomesinstudiesinvolvingpregnantmammalsexposuretonontobacconicotineasystematicscopingreview |