EPHA2 promotes triple-negative breast cancer progression by suppressing pyroptosis via the AKT/PI3K/mTOR pathway

EPHA2 promotes triple-negative breast cancer progression by suppressing pyroptosis via the AKT/PI3K/mTOR pathway

BackgroundBreast cancer (BRCA) is the most prevalent cancer in women, with triple-negative breast cancer (TNBC) accounting for 15-20% of cases. TNBC is associated with higher rates of metastasis, recurrence, and poorer prognosis, underscoring the urgent need for new diagnostic and therapeutic strate...

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Bibliographic Details
Main Authors: Xiaoying Huang, Li Na, Qingkai Han, Qilun Liu, Ligang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
EPHA2
pyroptosis
SLC7A11
AKT/PI3K
triple-negative breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1620122/full
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