Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.

One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few cis expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. Trans-regulating mechanisms m...

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Main Authors: Maxime Rotival, Tanja Zeller, Philipp S Wild, Seraya Maouche, Silke Szymczak, Arne Schillert, Raphaele Castagné, Arne Deiseroth, Carole Proust, Jessy Brocheton, Tiphaine Godefroy, Claire Perret, Marine Germain, Medea Eleftheriadis, Christoph R Sinning, Renate B Schnabel, Edith Lubos, Karl J Lackner, Heidi Rossmann, Thomas Münzel, Augusto Rendon, Cardiogenics Consortium, Jeanette Erdmann, Panos Deloukas, Christian Hengstenberg, Patrick Diemert, Gilles Montalescot, Willem H Ouwehand, Nilesh J Samani, Heribert Schunkert, David-Alexandre Tregouet, Andreas Ziegler, Alison H Goodall, François Cambien, Laurence Tiret, Stefan Blankenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002367&type=printable
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