Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in France
ABSTRACTBackground Clinician’s choice of hypoallergenic formulas in the first-line management of cow’s milk protein allergy (CMPA) should be informed by evidence on clinical efficacy and cost-effectiveness.Objective We compare the cost-effectiveness of amino acid-based formula (AAF), extensively hyd...
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2023-12-01
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| Series: | Journal of Market Access & Health Policy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20016689.2022.2154418 |
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| author | Ana Teresa Paquete Rui Martins Mark P. Connolly Marie Meulle Nítida Pastor Grégoire Benoist Patrick Tounian |
| author_facet | Ana Teresa Paquete Rui Martins Mark P. Connolly Marie Meulle Nítida Pastor Grégoire Benoist Patrick Tounian |
| author_sort | Ana Teresa Paquete |
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| description | ABSTRACTBackground Clinician’s choice of hypoallergenic formulas in the first-line management of cow’s milk protein allergy (CMPA) should be informed by evidence on clinical efficacy and cost-effectiveness.Objective We compare the cost-effectiveness of amino acid-based formula (AAF), extensively hydrolyzed casein formula with Lactobacillus rhamnosus Gorbach Goldin (EHCF+LGG), extensively hydrolyzed whey formula (EHWF), and rice hydrolyzed formula (RHF) in non-breastfed children in France.Methods Immunotolerance and atopic manifestations’ prevalence were based on a prospective non-randomized study with a 36-month follow-up. Resource utilization was sourced from a survey of French clinicians, and unit costs were based on national data. Costs and health consequences were discounted at 2.5% annually. Results were reported using the Collective and French National Health Insurance perspectives.Results Children receiving EHCF+LGG were predicted to require less healthcare resources, given their reduced prevalence of CMPA symptoms at 3 years. In the base case, EHCF+LGG led to savings of at least €674 per child compared to AAF, EHWF, and RHF at 3 years, from both perspectives. Nutrition had the highest economic burden in CMPA, driven by hypoallergenic formulas and dietetic replacements costs. Results were robust to one-way and probabilistic sensitivity analyses.Conclusions EHCF+LGG was associated with more symptom-free time, higher immune tolerance, and lower costs. |
| format | Article |
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| institution | OA Journals |
| issn | 2001-6689 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
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| series | Journal of Market Access & Health Policy |
| spelling | doaj-art-1a29bbb2e7da4e1abab39b5a0ce1ab4a2025-08-20T02:01:15ZengMDPI AGJournal of Market Access & Health Policy2001-66892023-12-0111110.1080/20016689.2022.2154418Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in FranceAna Teresa Paquete0Rui Martins1Mark P. Connolly2Marie Meulle3Nítida Pastor4Grégoire Benoist5Patrick Tounian6Health Economics Unit, Health Economics Consultants, Global Market Access Solutions, St-Prex, SwitzerlandHealth Economics Unit, Health Economics Consultants, Global Market Access Solutions, St-Prex, SwitzerlandHealth Economics Unit, Health Economics Consultants, Global Market Access Solutions, St-Prex, SwitzerlandBenckiser Healthcare France, Reckitt Benckiser, Paris, FranceMedical and Scientific Affairs, Nutrition, Reckitt Benckiser, 47721, Evansville, IN, USADepartment of Pediatrics, CHU Ambroise Paré, APHP, 92100, Boulogne-Billancourt, FrancePediatric Nutrition and Gastroenterology Department, Trousseau hospital, APHP, Sorbonne University, Paris, FranceABSTRACTBackground Clinician’s choice of hypoallergenic formulas in the first-line management of cow’s milk protein allergy (CMPA) should be informed by evidence on clinical efficacy and cost-effectiveness.Objective We compare the cost-effectiveness of amino acid-based formula (AAF), extensively hydrolyzed casein formula with Lactobacillus rhamnosus Gorbach Goldin (EHCF+LGG), extensively hydrolyzed whey formula (EHWF), and rice hydrolyzed formula (RHF) in non-breastfed children in France.Methods Immunotolerance and atopic manifestations’ prevalence were based on a prospective non-randomized study with a 36-month follow-up. Resource utilization was sourced from a survey of French clinicians, and unit costs were based on national data. Costs and health consequences were discounted at 2.5% annually. Results were reported using the Collective and French National Health Insurance perspectives.Results Children receiving EHCF+LGG were predicted to require less healthcare resources, given their reduced prevalence of CMPA symptoms at 3 years. In the base case, EHCF+LGG led to savings of at least €674 per child compared to AAF, EHWF, and RHF at 3 years, from both perspectives. Nutrition had the highest economic burden in CMPA, driven by hypoallergenic formulas and dietetic replacements costs. Results were robust to one-way and probabilistic sensitivity analyses.Conclusions EHCF+LGG was associated with more symptom-free time, higher immune tolerance, and lower costs.https://www.tandfonline.com/doi/10.1080/20016689.2022.2154418Cow’s milk protein allergyCost-effectiveness analysischild nutrition sciencesmilk substitutesFrance |
| spellingShingle | Ana Teresa Paquete Rui Martins Mark P. Connolly Marie Meulle Nítida Pastor Grégoire Benoist Patrick Tounian Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in France Journal of Market Access & Health Policy Cow’s milk protein allergy Cost-effectiveness analysis child nutrition sciences milk substitutes France |
| title | Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in France |
| title_full | Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in France |
| title_fullStr | Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in France |
| title_full_unstemmed | Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in France |
| title_short | Cost-effectiveness of infant hypoallergenic formulas to manage cow’s milk protein allergy in France |
| title_sort | cost effectiveness of infant hypoallergenic formulas to manage cow s milk protein allergy in france |
| topic | Cow’s milk protein allergy Cost-effectiveness analysis child nutrition sciences milk substitutes France |
| url | https://www.tandfonline.com/doi/10.1080/20016689.2022.2154418 |
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