Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab)
Lena Truong, Takla R Anis, Layla Najibfard, Edwin Peck Pharmacy Department, Henry Mayo Newhall Hospital, Valencia, CA, USA, Emergency Department, Henry Mayo Newhall Hospital, Valencia, CA, USACorrespondence: Lena Truong, Email Truongl@henrymayo.com Takla R Anis, Email Takla.anis@gmail.comAbstract: C...
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Dove Medical Press
2025-03-01
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| Series: | Clinical Pharmacology: Advances and Applications |
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| author | Truong L Anis TR Najibfard L Peck E |
| author_facet | Truong L Anis TR Najibfard L Peck E |
| author_sort | Truong L |
| collection | DOAJ |
| description | Lena Truong, Takla R Anis, Layla Najibfard, Edwin Peck Pharmacy Department, Henry Mayo Newhall Hospital, Valencia, CA, USA, Emergency Department, Henry Mayo Newhall Hospital, Valencia, CA, USACorrespondence: Lena Truong, Email Truongl@henrymayo.com Takla R Anis, Email Takla.anis@gmail.comAbstract: Crotalidae polyvalent immune Fab (CroFab) is an antivenin that is FDA approved and commonly used to treat envenomations caused by North American pit vipers. Although CroFab has been widely used since the early 2000s, hypersensitivity reactions like type I, type IV, and angioedema have been reported in the literature. We present a case of CroFab induced hypersensitivity reaction in a 41-year-old male shortly after starting CroFab infusion. Furthermore, this patient developed anaphylaxis symptoms including: difficulty breathing, oropharyngeal edema, dysphagia, wheezing, and chest tightness. This was resolved upon stopping CroFab infusion and administering epinephrine, methylprednisolone, diphenhydramine, and famotidine. The reaction occurred again when CroFab was re-introduced despite infusing it at a much slower rate. Interestingly, this patient successfully tolerated crotalidae immune F(abʹ)2 (equine) antivenom (ANAVIP) upon switching him from CroFab. Hypersensitivity reactions to CroFab can be life-threatening and warrant immediate attention and treatment in a multidisciplinary setting.Keywords: CroFab, ANAVIP, hypersensitivity reactions, anaphylaxis, snake bites |
| format | Article |
| id | doaj-art-1a2983fcdfde41c5a07f82a309a146f3 |
| institution | OA Journals |
| issn | 1179-1438 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Pharmacology: Advances and Applications |
| spelling | doaj-art-1a2983fcdfde41c5a07f82a309a146f32025-08-20T01:57:20ZengDove Medical PressClinical Pharmacology: Advances and Applications1179-14382025-03-01Volume 172528100972Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab)Truong LAnis TRNajibfard LPeck ELena Truong, Takla R Anis, Layla Najibfard, Edwin Peck Pharmacy Department, Henry Mayo Newhall Hospital, Valencia, CA, USA, Emergency Department, Henry Mayo Newhall Hospital, Valencia, CA, USACorrespondence: Lena Truong, Email Truongl@henrymayo.com Takla R Anis, Email Takla.anis@gmail.comAbstract: Crotalidae polyvalent immune Fab (CroFab) is an antivenin that is FDA approved and commonly used to treat envenomations caused by North American pit vipers. Although CroFab has been widely used since the early 2000s, hypersensitivity reactions like type I, type IV, and angioedema have been reported in the literature. We present a case of CroFab induced hypersensitivity reaction in a 41-year-old male shortly after starting CroFab infusion. Furthermore, this patient developed anaphylaxis symptoms including: difficulty breathing, oropharyngeal edema, dysphagia, wheezing, and chest tightness. This was resolved upon stopping CroFab infusion and administering epinephrine, methylprednisolone, diphenhydramine, and famotidine. The reaction occurred again when CroFab was re-introduced despite infusing it at a much slower rate. Interestingly, this patient successfully tolerated crotalidae immune F(abʹ)2 (equine) antivenom (ANAVIP) upon switching him from CroFab. Hypersensitivity reactions to CroFab can be life-threatening and warrant immediate attention and treatment in a multidisciplinary setting.Keywords: CroFab, ANAVIP, hypersensitivity reactions, anaphylaxis, snake biteshttps://www.dovepress.com/hypersensitivity-reaction-after-administration-of-crotalidae-polyvalen-peer-reviewed-fulltext-article-CPAAcrofabanaviphypersensitivity reactionsanaphylaxissnake bites. |
| spellingShingle | Truong L Anis TR Najibfard L Peck E Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab) Clinical Pharmacology: Advances and Applications crofab anavip hypersensitivity reactions anaphylaxis snake bites. |
| title | Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab) |
| title_full | Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab) |
| title_fullStr | Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab) |
| title_full_unstemmed | Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab) |
| title_short | Hypersensitivity Reaction After Administration of Crotalidae Polyvalent Immune Fab (CroFab) |
| title_sort | hypersensitivity reaction after administration of crotalidae polyvalent immune fab crofab |
| topic | crofab anavip hypersensitivity reactions anaphylaxis snake bites. |
| url | https://www.dovepress.com/hypersensitivity-reaction-after-administration-of-crotalidae-polyvalen-peer-reviewed-fulltext-article-CPAA |
| work_keys_str_mv | AT truongl hypersensitivityreactionafteradministrationofcrotalidaepolyvalentimmunefabcrofab AT anistr hypersensitivityreactionafteradministrationofcrotalidaepolyvalentimmunefabcrofab AT najibfardl hypersensitivityreactionafteradministrationofcrotalidaepolyvalentimmunefabcrofab AT pecke hypersensitivityreactionafteradministrationofcrotalidaepolyvalentimmunefabcrofab |