Higher C-reactive protein/albumin ratio is a potential marker for predicting amputation in patients with diabetic foot infection

Higher C-reactive protein/albumin ratio is a potential marker for predicting amputation in patients with diabetic foot infection

ABSTRACT Objective: Non-traumatic amputation resulting from diabetic foot infection (DFI) poses significant clinical and public health concerns. The C-reactive protein (CRP)/albumin ratio represents a combination of the infection level and nutritional status. This study investigated the relationshi...

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Bibliographic Details
Main Authors: Li Zhang, Xufeng Gao, Meifang He, Wenyan Wang, Yuebin Zhao
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2025-07-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Diabetic foot infection
C-reactive protein
albumin
amputation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301101&lng=en&tlng=en
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Summary:ABSTRACT Objective: Non-traumatic amputation resulting from diabetic foot infection (DFI) poses significant clinical and public health concerns. The C-reactive protein (CRP)/albumin ratio represents a combination of the infection level and nutritional status. This study investigated the relationship between the CRP/albumin ratio and amputation in patients with diabetic foot infections. Subjects and methods: Patients with a DFI of Wagner grade. 3 diagnosed between January 2020 and September 2023 were retrospectively analyzed. The association between the CRP/albumin ratio and amputation was explored using multivariable logistic regression modeling. Stratified analyses were also performed to ensure the reliability of the findings. Results: Of 301 enrolled patients, 226 underwent amputation and 75 did not. The amputation rate increased with a greater CRP/albumin ratio in the non-adjusted, minimally adjusted, and fully adjusted models, regardless of whether the CRP/albumin ratio was regarded as a categorical or continuous variable. Conclusion: An increased CRP/albumin ratio was associated with a greater risk of amputation in individuals with DFI.
ISSN:2359-4292

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