Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer
In recent years, mitochondrial transfer has emerged as a universal phenomenon intertwined with various systemic physiological and pathological processes. Alzheimer’s disease (AD) is a multifactorial disease, with mitochondrial dysfunction at its core. Although numerous studies have found evidence of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1517965/full |
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| author | Yun Wei Xinlei Du Hongling Guo Jingjing Han Meixia Liu |
| author_facet | Yun Wei Xinlei Du Hongling Guo Jingjing Han Meixia Liu |
| author_sort | Yun Wei |
| collection | DOAJ |
| description | In recent years, mitochondrial transfer has emerged as a universal phenomenon intertwined with various systemic physiological and pathological processes. Alzheimer’s disease (AD) is a multifactorial disease, with mitochondrial dysfunction at its core. Although numerous studies have found evidence of mitochondrial transfer in AD models, the precise mechanisms remain unclear. Recent studies have revealed the dynamic transfer of mitochondria in Alzheimer’s disease, not only between nerve cells and glial cells, but also between nerve cells and glial cells. In this review, we explore the pathways and mechanisms of mitochondrial transfer in Alzheimer’s disease and how these transfer activities contribute to disease progression. |
| format | Article |
| id | doaj-art-1a22b841021f4e8088a1eab887060a67 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-1a22b841021f4e8088a1eab887060a672024-12-17T06:23:20ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-12-011610.3389/fnagi.2024.15179651517965Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transferYun WeiXinlei DuHongling GuoJingjing HanMeixia LiuIn recent years, mitochondrial transfer has emerged as a universal phenomenon intertwined with various systemic physiological and pathological processes. Alzheimer’s disease (AD) is a multifactorial disease, with mitochondrial dysfunction at its core. Although numerous studies have found evidence of mitochondrial transfer in AD models, the precise mechanisms remain unclear. Recent studies have revealed the dynamic transfer of mitochondria in Alzheimer’s disease, not only between nerve cells and glial cells, but also between nerve cells and glial cells. In this review, we explore the pathways and mechanisms of mitochondrial transfer in Alzheimer’s disease and how these transfer activities contribute to disease progression.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1517965/fullAlzheimer’s diseasemitochondrial transfermitochondrial dysfunctionneuroprotectionAD treatment |
| spellingShingle | Yun Wei Xinlei Du Hongling Guo Jingjing Han Meixia Liu Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer Frontiers in Aging Neuroscience Alzheimer’s disease mitochondrial transfer mitochondrial dysfunction neuroprotection AD treatment |
| title | Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer |
| title_full | Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer |
| title_fullStr | Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer |
| title_full_unstemmed | Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer |
| title_short | Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer |
| title_sort | mitochondrial dysfunction and alzheimer s disease pathogenesis of mitochondrial transfer |
| topic | Alzheimer’s disease mitochondrial transfer mitochondrial dysfunction neuroprotection AD treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1517965/full |
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