Biosimilars in Retinal Diseases: A Primer

Retinal disease management has witnessed remarkable advances with the development of anti-VEGF molecules such as Lucentis® (ranibizumab), Eylea® (aflibercept), off-label bevacizumab (Avastin) and the latest molecule Brolucizumab i n the management of various retinal diseases such as diabetic macular...

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Bibliographic Details
Main Authors: Rashmi Rawat, Rushil Kumar Saxena, Manisha Agarwal
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-04-01
Series:Delhi Journal of Ophthalmology
Subjects:
Online Access:https://journals.lww.com/10.4103/DLJO.DLJO_132_23
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Summary:Retinal disease management has witnessed remarkable advances with the development of anti-VEGF molecules such as Lucentis® (ranibizumab), Eylea® (aflibercept), off-label bevacizumab (Avastin) and the latest molecule Brolucizumab i n the management of various retinal diseases such as diabetic macular oedema, neovascular age-related macular degeneration (AMD), and retinal vein occlusions. Patients usually need multiple and frequent dosing of these agents that cause increased financial burden and other unique challenges to the patients. Biosimilar molecules in future can potentially come in the mainstream clinical practice as a more cost-effective choice. It is important for clinicians to have a clear understanding about ophthalmic biosimilars before the industry brings these molecules to mainstream clinical use globally. This article provides an update on biosimilars and will help postgraduates to get a clear view about the various biosimilars that are already in use and those that are in pipeline.
ISSN:0972-0200
2454-2784