Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma
Aim. To present a case of clear cell renal cell carcinoma with late-onset bilateral choroidal metastases. Case Report. A 57-year-old male patient in the Oncology Clinic complained of reduced vision in the right eye (OD) for 7 days. The patient, who was under immunotherapy with nivolumab, had been di...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2020/8862203 |
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| author | Constantinos D. Georgakopoulos Athina Pallikari Panagiotis Plotas Olga E. Makri |
| author_facet | Constantinos D. Georgakopoulos Athina Pallikari Panagiotis Plotas Olga E. Makri |
| author_sort | Constantinos D. Georgakopoulos |
| collection | DOAJ |
| description | Aim. To present a case of clear cell renal cell carcinoma with late-onset bilateral choroidal metastases. Case Report. A 57-year-old male patient in the Oncology Clinic complained of reduced vision in the right eye (OD) for 7 days. The patient, who was under immunotherapy with nivolumab, had been diagnosed with clear cell renal cell carcinoma in the left kidney 15 years ago that recurred in the right kidney before 2 years. Metastases in the brain, lungs, and bones had also been diagnosed. On ophthalmological examination, the visual acuity was 20/50 OD and 20/20 in the left eye (OS). Dilated fundus examination in OD revealed a single raised oval-shaped yellowish choroidal nodule infratemporally with macular involvement. A similar lesion, sparing the macula, was observed in OS. Fundus autofluorescence revealed diffuse punctate hyperautofluorescence on the lesions. Serous macular detachment was also observed in OD. A standardized A-scan ultrasound demonstrated an irregular structure of the lesions with moderate to high internal reflectivity. Based on the history and clinical and echographic characteristics, the diagnosis of bilateral choroidal metastases from renal cell carcinoma was set. Conclusion. Choroidal metastases from the primary renal tumor are extremely rare. The time interval between primary malignancy and choroidal metastasis is reported to be 12-96 months. Bilateral choroidal metastases have been described in 9 cases. We describe a rare case where bilateral choroidal metastases were diagnosed 15 years after the initial diagnosis of clear cell renal cell carcinoma. |
| format | Article |
| id | doaj-art-1a161764bdeb49e19f1ca239cc6f0c4d |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-1a161764bdeb49e19f1ca239cc6f0c4d2025-02-03T06:43:52ZengWileyCase Reports in Urology2090-696X2090-69782020-01-01202010.1155/2020/88622038862203Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell CarcinomaConstantinos D. Georgakopoulos0Athina Pallikari1Panagiotis Plotas2Olga E. Makri3Department of Ophthalmology, Medical School, University of Patras, Rio, 265 04 Patras, GreeceDepartment of Ophthalmology, Medical School, University of Patras, Rio, 265 04 Patras, GreeceDepartment of Ophthalmology, Medical School, University of Patras, Rio, 265 04 Patras, GreeceDepartment of Ophthalmology, Medical School, University of Patras, Rio, 265 04 Patras, GreeceAim. To present a case of clear cell renal cell carcinoma with late-onset bilateral choroidal metastases. Case Report. A 57-year-old male patient in the Oncology Clinic complained of reduced vision in the right eye (OD) for 7 days. The patient, who was under immunotherapy with nivolumab, had been diagnosed with clear cell renal cell carcinoma in the left kidney 15 years ago that recurred in the right kidney before 2 years. Metastases in the brain, lungs, and bones had also been diagnosed. On ophthalmological examination, the visual acuity was 20/50 OD and 20/20 in the left eye (OS). Dilated fundus examination in OD revealed a single raised oval-shaped yellowish choroidal nodule infratemporally with macular involvement. A similar lesion, sparing the macula, was observed in OS. Fundus autofluorescence revealed diffuse punctate hyperautofluorescence on the lesions. Serous macular detachment was also observed in OD. A standardized A-scan ultrasound demonstrated an irregular structure of the lesions with moderate to high internal reflectivity. Based on the history and clinical and echographic characteristics, the diagnosis of bilateral choroidal metastases from renal cell carcinoma was set. Conclusion. Choroidal metastases from the primary renal tumor are extremely rare. The time interval between primary malignancy and choroidal metastasis is reported to be 12-96 months. Bilateral choroidal metastases have been described in 9 cases. We describe a rare case where bilateral choroidal metastases were diagnosed 15 years after the initial diagnosis of clear cell renal cell carcinoma.http://dx.doi.org/10.1155/2020/8862203 |
| spellingShingle | Constantinos D. Georgakopoulos Athina Pallikari Panagiotis Plotas Olga E. Makri Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma Case Reports in Urology |
| title | Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma |
| title_full | Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma |
| title_fullStr | Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma |
| title_full_unstemmed | Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma |
| title_short | Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma |
| title_sort | late onset bilateral choroidal metastases from clear cell renal cell carcinoma |
| url | http://dx.doi.org/10.1155/2020/8862203 |
| work_keys_str_mv | AT constantinosdgeorgakopoulos lateonsetbilateralchoroidalmetastasesfromclearcellrenalcellcarcinoma AT athinapallikari lateonsetbilateralchoroidalmetastasesfromclearcellrenalcellcarcinoma AT panagiotisplotas lateonsetbilateralchoroidalmetastasesfromclearcellrenalcellcarcinoma AT olgaemakri lateonsetbilateralchoroidalmetastasesfromclearcellrenalcellcarcinoma |