Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/821043 |
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| _version_ | 1849308709795135488 |
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| author | Beatriz Sangiuliano Nancy Marcela Pérez Dayson F. Moreira José E. Belizário |
| author_facet | Beatriz Sangiuliano Nancy Marcela Pérez Dayson F. Moreira José E. Belizário |
| author_sort | Beatriz Sangiuliano |
| collection | DOAJ |
| description | Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and mitochondria. These endogenous factors are named cell death-associated molecular-pattern (CDAMP), damage-associated molecular-pattern (DAMP) molecules, and alarmins. Some of them cooperate or act as important initial or delayed inflammatory mediators upon binding to diverse membrane and cytosolic receptors coupled to signaling pathways for the activation of the inflammasome platforms and NF-κB multiprotein complexes. Current studies show that the nonprotein thiols and thiol-regulating enzymes as well as highly diffusible prooxidant reactive oxygen and nitrogen species released together in extracellular inflammatory milieu play essential role in controlling pro- and anti-inflammatory activities of CDAMP/DAMP and alarmins. Here, we provide an overview of these emerging concepts and mechanisms of triggering and maintenance of tissue inflammation under massive death of cells. |
| format | Article |
| id | doaj-art-1a0eda8e0dac4cf388c7eecfdee54833 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1a0eda8e0dac4cf388c7eecfdee548332025-08-20T03:54:21ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/821043821043Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and ControlBeatriz Sangiuliano0Nancy Marcela Pérez1Dayson F. Moreira2José E. Belizário3Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilApoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and mitochondria. These endogenous factors are named cell death-associated molecular-pattern (CDAMP), damage-associated molecular-pattern (DAMP) molecules, and alarmins. Some of them cooperate or act as important initial or delayed inflammatory mediators upon binding to diverse membrane and cytosolic receptors coupled to signaling pathways for the activation of the inflammasome platforms and NF-κB multiprotein complexes. Current studies show that the nonprotein thiols and thiol-regulating enzymes as well as highly diffusible prooxidant reactive oxygen and nitrogen species released together in extracellular inflammatory milieu play essential role in controlling pro- and anti-inflammatory activities of CDAMP/DAMP and alarmins. Here, we provide an overview of these emerging concepts and mechanisms of triggering and maintenance of tissue inflammation under massive death of cells.http://dx.doi.org/10.1155/2014/821043 |
| spellingShingle | Beatriz Sangiuliano Nancy Marcela Pérez Dayson F. Moreira José E. Belizário Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control Mediators of Inflammation |
| title | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
| title_full | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
| title_fullStr | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
| title_full_unstemmed | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
| title_short | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
| title_sort | cell death associated molecular pattern molecules inflammatory signaling and control |
| url | http://dx.doi.org/10.1155/2014/821043 |
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