A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of skeletal muscle fatty acid catabolism, glucose homeostasis, and cellular differentiation has been established...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/534294 |
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| _version_ | 1832556536578179072 |
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| author | Rolf Müller Martin Kömhoff Jeffrey M. Peters Sabine Müller-Brüsselbach |
| author_facet | Rolf Müller Martin Kömhoff Jeffrey M. Peters Sabine Müller-Brüsselbach |
| author_sort | Rolf Müller |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of skeletal muscle fatty acid catabolism, glucose homeostasis, and cellular differentiation has been established in multiple studies. On the contrary, a role for PPARβ/δ in tumorigenesis is less clear because there are contradictory reports in the literature. However, the majority of these studies have not examined the role of PPARβ/δ in the tumor stroma. Recent evidence suggests that stromal PPARβ/δ regulates tumor endothelial cell proliferation and promotes differentiation leading to the properly orchestrated events required for tumor blood vessel formation. This review briefly summarizes the significance of these studies that may provide clues to help explain the reported discrepancies in the literature regarding the role of PPARβ/δ in tumorigenesis. |
| format | Article |
| id | doaj-art-1a0c22c3fed0489690919c2f4584f391 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-1a0c22c3fed0489690919c2f4584f3912025-02-03T05:44:57ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/534294534294A Role for PPARβ/δ in Tumor Stroma and TumorigenesisRolf Müller0Martin Kömhoff1Jeffrey M. Peters2Sabine Müller-Brüsselbach3Institute of Molecular Biology and Tumor Research (IMT), Philipps-University, Emil-Mannkopff-Strasse 2, 35032 Marburg, GermanyDepartment of Pediatrics, Philipps-University, Baldingerstrasse, 35043 Marburg, GermanyDepartment of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, 312 Life Sciences Building, The Pennsylvania State University, University Park, PA 16802-1504, USAInstitute of Molecular Biology and Tumor Research (IMT), Philipps-University, Emil-Mannkopff-Strasse 2, 35032 Marburg, GermanyPeroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of skeletal muscle fatty acid catabolism, glucose homeostasis, and cellular differentiation has been established in multiple studies. On the contrary, a role for PPARβ/δ in tumorigenesis is less clear because there are contradictory reports in the literature. However, the majority of these studies have not examined the role of PPARβ/δ in the tumor stroma. Recent evidence suggests that stromal PPARβ/δ regulates tumor endothelial cell proliferation and promotes differentiation leading to the properly orchestrated events required for tumor blood vessel formation. This review briefly summarizes the significance of these studies that may provide clues to help explain the reported discrepancies in the literature regarding the role of PPARβ/δ in tumorigenesis.http://dx.doi.org/10.1155/2008/534294 |
| spellingShingle | Rolf Müller Martin Kömhoff Jeffrey M. Peters Sabine Müller-Brüsselbach A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis PPAR Research |
| title | A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis |
| title_full | A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis |
| title_fullStr | A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis |
| title_full_unstemmed | A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis |
| title_short | A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis |
| title_sort | role for pparβ δ in tumor stroma and tumorigenesis |
| url | http://dx.doi.org/10.1155/2008/534294 |
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