Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study)

Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study)

By now the pegylation of biologically active molecules including proteins with an inert hydrophilic polymer polyethylene glycol (PEG) is an important area in the new generation of prolonged-action pharmaceutical preparations. The conjugated molecules usually have an improved pharmacokinetic profile,...

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Bibliographic Details
Main Authors: I. А. Puchkov, D. I. Bairamashvili, V. I. Shvets
Format: Article
Language:Russian
Published: MIREA - Russian Technological University 2014-04-01
Series:Тонкие химические технологии
Subjects:
polyethylene glycol (peg), biopharmaceutical drugs, granulocyte colony-stimulating factor (g-csf), modification, cytokines, pharmacokinetic profile.
Online Access:https://www.finechem-mirea.ru/jour/article/view/478
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