CD117 (KIT) in canine soft tissue sarcoma: an immunohistochemical and c-kit gene mutation assessment

CD117 (KIT) in canine soft tissue sarcoma: an immunohistochemical and c-kit gene mutation assessment

IntroductionCanine soft tissue sarcomas (STSs) are locally aggressive mesenchymal tumors with variable recurrence rates, and often, their therapy is limited to surgical excision. CD117 (KIT) is a tyrosine kinase receptor involved in cell growth and cancer development. c-kit proto-oncogene mutations...

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Bibliographic Details
Main Authors: Silvia Dell’Aere, Valentina Balbi, Damiano Stefanello, Giancarlo Avallone, Gabriele Ghisleni, Stefano Perfetto, Roberta Ferrari, Luigi Auletta, Elisa Maria Gariboldi, Alessandra Ubiali, Caterina Romanello, Alessandra Verdi, Paola Roccabianca
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Veterinary Science
Subjects:
canine
CD117
KIT
soft tissue sarcoma
therapeutical target
tyrosine kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1572923/full
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