Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling

Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling

Abstract Isthmin-1 (ISM1) is a recently described adipokine with insulin-like properties that can control hyperglycemia and liver steatosis. Additionally, ISM1 is proposed to play critical roles in patterning, angiogenesis, vascular permeability, and apoptosis. A key feature of ISM1 is its AMOP (adh...

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Bibliographic Details
Main Authors: Tongqing Li, Steven E. Stayrook, Wenxue Li, Yueyue Wang, Hengyi Li, Jianan Zhang, Yansheng Liu, Daryl E. Klein
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58828-w
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