STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer

STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) poses a serious clinical challenge, demanding further exploration of its pathogenesis and therapeutic targets for metastasis, the main cause of mortality. Here, we identify STN1, a CST complex member crucial for maintaining telomere lengths and genome...

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Bibliographic Details
Main Authors: Di Dong, Zhe Zhou, Minglu Zhu, Zhiyuan Hou, Mo Chen, Jingjing Gong, Xuyang Zhao, Aohui Yan, Hui Liang, Yuxin Yin
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63083-0
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