The Impact of brain-gut microbiota composition on depression
Introduction and Purpose: Recently, depression has significantly marked its presence in both the scientific and social spheres due to its connections with suicides. According to WHO data, it affects approximately 280 million people and as much as 5% of all adults worldwide. The primary treatment fo...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2024-11-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/56220 |
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| author | Aleksander Ptasiński Marta Targońska Oskar Targoński Adrianna Madej Adrian Suława Julia Furgalska Sebastian Fedorowicz Aneta Basiak Rafał Niekurzak Agnieszka Buczek |
| author_facet | Aleksander Ptasiński Marta Targońska Oskar Targoński Adrianna Madej Adrian Suława Julia Furgalska Sebastian Fedorowicz Aneta Basiak Rafał Niekurzak Agnieszka Buczek |
| author_sort | Aleksander Ptasiński |
| collection | DOAJ |
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Introduction and Purpose: Recently, depression has significantly marked its presence in both the scientific and social spheres due to its connections with suicides. According to WHO data, it affects approximately 280 million people and as much as 5% of all adults worldwide. The primary treatment for this condition includes drugs such as SSRIs and SNRIs. However, in the last decade, numerous studies have demonstrated the impact of gut bacteria dysbiosis on brain functions and, consequently, its role in the pathogenesis of depression. Therefore, this paper focuses on the mechanisms and factors that negatively or positively affect the state of gut microbiota leading to depression, as well as on modern intervention methods in this field.
State of Knowledge: Recent clinical studies highlight that gut bacteria, in connection with the immune system, can influence brain function, including the pathogenesis of depression. According to scientists, this influence occurs through bacteria present in the gut, their metabolism, and its products. However, depending on the composition of the gut microbiota (i.e., bacterial taxa), the substances produced in the gut can have a positive or negative impact on brain function regulation, thus contributing to an increased risk of depression symptoms or to their alleviation and remission.
Summary: This review paper describes the currently known factors that negatively or positively affect the maintenance of a healthy gut microbiota composition, their effectiveness in microbiome modulation, and potential methods for treating gut bacterial dysbiosis, which often coexists in patients suffering from depression. It is important to note the significant individual variability in the context of changes in the depressive microbiome and the response to various modification methods. Therefore, when selecting appropriate therapy, cooperation with the patient will be crucial to achieve satisfactory results and avoid adverse effects.
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| format | Article |
| id | doaj-art-1a0035e149bb4beda40a72b012b903a1 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-1a0035e149bb4beda40a72b012b903a12024-11-26T08:09:31ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182024-11-013410.12775/QS.2024.34.56220The Impact of brain-gut microbiota composition on depressionAleksander Ptasiński0Marta Targońska1Oskar TargońskiAdrianna MadejAdrian SuławaJulia FurgalskaSebastian FedorowiczAneta BasiakRafał NiekurzakAgnieszka BuczekIntern DoctorPublic University Hospital No. 1 in Lublin Introduction and Purpose: Recently, depression has significantly marked its presence in both the scientific and social spheres due to its connections with suicides. According to WHO data, it affects approximately 280 million people and as much as 5% of all adults worldwide. The primary treatment for this condition includes drugs such as SSRIs and SNRIs. However, in the last decade, numerous studies have demonstrated the impact of gut bacteria dysbiosis on brain functions and, consequently, its role in the pathogenesis of depression. Therefore, this paper focuses on the mechanisms and factors that negatively or positively affect the state of gut microbiota leading to depression, as well as on modern intervention methods in this field. State of Knowledge: Recent clinical studies highlight that gut bacteria, in connection with the immune system, can influence brain function, including the pathogenesis of depression. According to scientists, this influence occurs through bacteria present in the gut, their metabolism, and its products. However, depending on the composition of the gut microbiota (i.e., bacterial taxa), the substances produced in the gut can have a positive or negative impact on brain function regulation, thus contributing to an increased risk of depression symptoms or to their alleviation and remission. Summary: This review paper describes the currently known factors that negatively or positively affect the maintenance of a healthy gut microbiota composition, their effectiveness in microbiome modulation, and potential methods for treating gut bacterial dysbiosis, which often coexists in patients suffering from depression. It is important to note the significant individual variability in the context of changes in the depressive microbiome and the response to various modification methods. Therefore, when selecting appropriate therapy, cooperation with the patient will be crucial to achieve satisfactory results and avoid adverse effects. https://apcz.umk.pl/QS/article/view/56220Microbiota transplantationdepressiondepression-associated microbiomegut-brain axisdietary interventions in depression |
| spellingShingle | Aleksander Ptasiński Marta Targońska Oskar Targoński Adrianna Madej Adrian Suława Julia Furgalska Sebastian Fedorowicz Aneta Basiak Rafał Niekurzak Agnieszka Buczek The Impact of brain-gut microbiota composition on depression Quality in Sport Microbiota transplantation depression depression-associated microbiome gut-brain axis dietary interventions in depression |
| title | The Impact of brain-gut microbiota composition on depression |
| title_full | The Impact of brain-gut microbiota composition on depression |
| title_fullStr | The Impact of brain-gut microbiota composition on depression |
| title_full_unstemmed | The Impact of brain-gut microbiota composition on depression |
| title_short | The Impact of brain-gut microbiota composition on depression |
| title_sort | impact of brain gut microbiota composition on depression |
| topic | Microbiota transplantation depression depression-associated microbiome gut-brain axis dietary interventions in depression |
| url | https://apcz.umk.pl/QS/article/view/56220 |
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