A neurally constrained computational model of context-dependent fear extinction recall and relapse
Abstract Exposure therapy, a standard treatment for anxiety disorders, relies on fear extinction. However, extinction recall is often limited to the spatial and temporal context in which extinction is learned, leading to fear relapse in new settings or after delays. Animal studies offer insights int...
Saved in:
| Main Authors: | Shreya K. Rajagopal, Thad A. Polk |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08107-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Targeted NMDA receptor knockdown in recall‐activated neuronal ensembles impairs remote fear extinction
by: Yongmin Sung, et al.
Published: (2025-04-01) -
High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway
by: Alyssa A. Hohorst, et al.
Published: (2025-06-01) -
The Regulation of Cytokine Networks in Hippocampal CA1 Differentiates Extinction from Those Required for the Maintenance of Contextual Fear Memory after Recall.
by: Birger Scholz, et al.
Published: (2016-01-01) -
Effects of aerobic running vs. reading rest after fear extinction on recall: Decreased prefrontal cortex activity to distinguish threat and safety cues
by: Xiao Zhou, et al.
Published: (2025-09-01) -
Human fear conditioning and extinction in neuroimaging: a systematic review.
by: Christina Sehlmeyer, et al.
Published: (2009-06-01)