Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic Challenge
ABSTRACT Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive malignancy that often presents atypically, leading to incomplete diagnosis. We report a 55‐year‐old male with chronic obstructive pulmonary disease who presented with productive cough and haemoptysis. Initial bronchoscopy reveal...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
|
| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.70213 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850139132048703488 |
|---|---|
| author | YingYing Qian |
| author_facet | YingYing Qian |
| author_sort | YingYing Qian |
| collection | DOAJ |
| description | ABSTRACT Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive malignancy that often presents atypically, leading to incomplete diagnosis. We report a 55‐year‐old male with chronic obstructive pulmonary disease who presented with productive cough and haemoptysis. Initial bronchoscopy revealed fungal hyphae consistent with Aspergillus infection. The misleading clinical presentation led to an incomplete diagnosis. Subsequent lung biopsy and immunohistochemistry confirmed PSC harbouring an EGFR L858R mutation. Despite the presence of a targetable mutation, the patient showed a poor response to EGFR‐targeted therapy. This case highlights the diagnostic challenges and therapeutic complexities when PSC coexists with an airway fungal infection. |
| format | Article |
| id | doaj-art-19fa385b344646b19b3ba2adada9dc60 |
| institution | OA Journals |
| issn | 2051-3380 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj-art-19fa385b344646b19b3ba2adada9dc602025-08-20T02:30:24ZengWileyRespirology Case Reports2051-33802025-05-01135n/an/a10.1002/rcr2.70213Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic ChallengeYingYing Qian0Department of Geriatrics, Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou ChinaABSTRACT Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive malignancy that often presents atypically, leading to incomplete diagnosis. We report a 55‐year‐old male with chronic obstructive pulmonary disease who presented with productive cough and haemoptysis. Initial bronchoscopy revealed fungal hyphae consistent with Aspergillus infection. The misleading clinical presentation led to an incomplete diagnosis. Subsequent lung biopsy and immunohistochemistry confirmed PSC harbouring an EGFR L858R mutation. Despite the presence of a targetable mutation, the patient showed a poor response to EGFR‐targeted therapy. This case highlights the diagnostic challenges and therapeutic complexities when PSC coexists with an airway fungal infection.https://doi.org/10.1002/rcr2.70213aspergillosischemotherapyEGFR mutationmisdiagnosispulmonary sarcomatoid carcinoma |
| spellingShingle | YingYing Qian Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic Challenge Respirology Case Reports aspergillosis chemotherapy EGFR mutation misdiagnosis pulmonary sarcomatoid carcinoma |
| title | Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic Challenge |
| title_full | Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic Challenge |
| title_fullStr | Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic Challenge |
| title_full_unstemmed | Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic Challenge |
| title_short | Pulmonary Sarcomatoid Carcinoma Initially Misdiagnosed as Aspergillosis: A Diagnostic Challenge |
| title_sort | pulmonary sarcomatoid carcinoma initially misdiagnosed as aspergillosis a diagnostic challenge |
| topic | aspergillosis chemotherapy EGFR mutation misdiagnosis pulmonary sarcomatoid carcinoma |
| url | https://doi.org/10.1002/rcr2.70213 |
| work_keys_str_mv | AT yingyingqian pulmonarysarcomatoidcarcinomainitiallymisdiagnosedasaspergillosisadiagnosticchallenge |