Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion
Objectives. Bile duct invasion (BDI) is a rare event in hepatocellular carcinoma (HCC). The present study aimed at investigating clinical characteristics and surgical outcome of HCC patients with bile duct invasion. Methods. 413 patients with HCC undergoing curative surgery were divided into two gro...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/604971 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545351271186432 |
|---|---|
| author | Ke-Wei Meng Mei Dong Wei-Guo Zhang Qing-Xian Huang |
| author_facet | Ke-Wei Meng Mei Dong Wei-Guo Zhang Qing-Xian Huang |
| author_sort | Ke-Wei Meng |
| collection | DOAJ |
| description | Objectives. Bile duct invasion (BDI) is a rare event in hepatocellular carcinoma (HCC). The present study aimed at investigating clinical characteristics and surgical outcome of HCC patients with bile duct invasion. Methods. 413 patients with HCC undergoing curative surgery were divided into two groups with (B+) and without BDI (B−). BDI was further classified as central type (B1) and peripheral type (B2). Survival was compared, and risk factors affecting prognosis were identified. Results. 35 (8.5%) patients were diagnosed BDI. Total bilirubin was significantly higher in B+ group than in B− group (P<0.001). Multiple lesions and large nodules (>5 cm) were predominantly identified in B+ group (P<0.01, resp.). Portal vein invasion was more frequently observed in B+ than in B− group (P=0.003). Univariate and multivariate analyses identified central BDI as a significant factor affecting prognosis of HCC patients (risk 1.3, 95% CI 1.1–2.2, P=0.015). The gross overall survival of patients in B+ was significantly worse than in B− (P=0.001), which, however, was not different between B2 and B− (P>0.05). Conclusions. Central but not peripheral BDI was associated with poorer prognosis of HCC patients. Curative surgical resection of tumors and invaded bile duct supplies the only hope for long-term survival of patients. |
| format | Article |
| id | doaj-art-19f929813d2e4e4a8772851ace5ca4bd |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-19f929813d2e4e4a8772851ace5ca4bd2025-02-03T07:26:04ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/604971604971Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct InvasionKe-Wei Meng0Mei Dong1Wei-Guo Zhang2Qing-Xian Huang3Department of Hepatobiliary Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, ChinaDepartment of Hepatobiliary Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, ChinaDepartment of Hepatobiliary Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, ChinaDepartment of Hepatobiliary Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, ChinaObjectives. Bile duct invasion (BDI) is a rare event in hepatocellular carcinoma (HCC). The present study aimed at investigating clinical characteristics and surgical outcome of HCC patients with bile duct invasion. Methods. 413 patients with HCC undergoing curative surgery were divided into two groups with (B+) and without BDI (B−). BDI was further classified as central type (B1) and peripheral type (B2). Survival was compared, and risk factors affecting prognosis were identified. Results. 35 (8.5%) patients were diagnosed BDI. Total bilirubin was significantly higher in B+ group than in B− group (P<0.001). Multiple lesions and large nodules (>5 cm) were predominantly identified in B+ group (P<0.01, resp.). Portal vein invasion was more frequently observed in B+ than in B− group (P=0.003). Univariate and multivariate analyses identified central BDI as a significant factor affecting prognosis of HCC patients (risk 1.3, 95% CI 1.1–2.2, P=0.015). The gross overall survival of patients in B+ was significantly worse than in B− (P=0.001), which, however, was not different between B2 and B− (P>0.05). Conclusions. Central but not peripheral BDI was associated with poorer prognosis of HCC patients. Curative surgical resection of tumors and invaded bile duct supplies the only hope for long-term survival of patients.http://dx.doi.org/10.1155/2014/604971 |
| spellingShingle | Ke-Wei Meng Mei Dong Wei-Guo Zhang Qing-Xian Huang Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion Gastroenterology Research and Practice |
| title | Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion |
| title_full | Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion |
| title_fullStr | Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion |
| title_full_unstemmed | Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion |
| title_short | Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion |
| title_sort | clinical characteristics and surgical prognosis of hepatocellular carcinoma with bile duct invasion |
| url | http://dx.doi.org/10.1155/2014/604971 |
| work_keys_str_mv | AT keweimeng clinicalcharacteristicsandsurgicalprognosisofhepatocellularcarcinomawithbileductinvasion AT meidong clinicalcharacteristicsandsurgicalprognosisofhepatocellularcarcinomawithbileductinvasion AT weiguozhang clinicalcharacteristicsandsurgicalprognosisofhepatocellularcarcinomawithbileductinvasion AT qingxianhuang clinicalcharacteristicsandsurgicalprognosisofhepatocellularcarcinomawithbileductinvasion |