Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice
Diabetes is prevalent worldwide, but ideally intensive therapeutic strategy in clinical diabetes and diabetic nephropathy (DN) is still lack. Pyruvate is protective from glucometabolic disturbances and kidney dysfunction in various pathogenic insults. Present studies focused on oral pyruvate effects...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2817972 |
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| author | Xiao Meng Zhang Hao Deng Jin Dong Tong Yi Zhen Wang Xu Chao Ning Xiu Hong Yang Fang Qiang Zhou Hui Min Jin |
| author_facet | Xiao Meng Zhang Hao Deng Jin Dong Tong Yi Zhen Wang Xu Chao Ning Xiu Hong Yang Fang Qiang Zhou Hui Min Jin |
| author_sort | Xiao Meng Zhang |
| collection | DOAJ |
| description | Diabetes is prevalent worldwide, but ideally intensive therapeutic strategy in clinical diabetes and diabetic nephropathy (DN) is still lack. Pyruvate is protective from glucometabolic disturbances and kidney dysfunction in various pathogenic insults. Present studies focused on oral pyruvate effects on diabetes status and DN with 0.35% pyruvate in pyruvate-enriched oral rehydration solution (Pyr-ORS) and 1% pyruvate as drinking water for 8 weeks, using the model of diabetic db/db mice. Both Pyr-ORS and 1% pyruvate showed comparable therapeutic effectiveness with controls of body weight and blood sugar, increases of blood insulin levels, and improvement of renal function and pathological changes. Aberrant key enzyme activities in glucometabolic pathways, AR, PK, and PDK/PDH, were also restored; indexes of oxidative stress and inflammation, NAD+/NADH ratio, and AGEs in the kidneys were mostly significantly preserved after pyruvate treatments. We concluded that oral pyruvate delayed DN progression in db/db mice and the modified Pyr-ORS formula might be an ideal novel therapeutic drink in clinical prevention and treatment of type 2 diabetes and DN. |
| format | Article |
| id | doaj-art-19f90c42aba74dc6b790a5b75a040c96 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-19f90c42aba74dc6b790a5b75a040c962025-02-03T06:46:40ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/28179722817972Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db MiceXiao Meng Zhang0Hao Deng1Jin Dong Tong2Yi Zhen Wang3Xu Chao Ning4Xiu Hong Yang5Fang Qiang Zhou6Hui Min Jin7Department of Nephrology, Pudong Hospital, Shanghai Medical School, Fudan University, 2800 Gong Wei Road, Shanghai, ChinaDepartment of Nephrology, Pudong Hospital, Shanghai Medical School, Fudan University, 2800 Gong Wei Road, Shanghai, ChinaDivision of Vascular surgery, Pudong Hospital, Shanghai Medical School, Fudan University, 2800 Gong Wei Road, Shanghai, ChinaDepartment of Clinical Medicine, Affiliated Hospital of Qingdao University, 16 Jiang Su Road, Qingdao, Shandong, ChinaDepartment of Clinical Medicine, Affiliated Hospital of Qingdao University, 16 Jiang Su Road, Qingdao, Shandong, ChinaDepartment of Nephrology, Pudong Hospital, Shanghai Medical School, Fudan University, 2800 Gong Wei Road, Shanghai, ChinaShanghai Sandai Pharmaceutical R&D Co., Ltd., Pudong, Shanghai, ChinaDepartment of Nephrology, Pudong Hospital, Shanghai Medical School, Fudan University, 2800 Gong Wei Road, Shanghai, ChinaDiabetes is prevalent worldwide, but ideally intensive therapeutic strategy in clinical diabetes and diabetic nephropathy (DN) is still lack. Pyruvate is protective from glucometabolic disturbances and kidney dysfunction in various pathogenic insults. Present studies focused on oral pyruvate effects on diabetes status and DN with 0.35% pyruvate in pyruvate-enriched oral rehydration solution (Pyr-ORS) and 1% pyruvate as drinking water for 8 weeks, using the model of diabetic db/db mice. Both Pyr-ORS and 1% pyruvate showed comparable therapeutic effectiveness with controls of body weight and blood sugar, increases of blood insulin levels, and improvement of renal function and pathological changes. Aberrant key enzyme activities in glucometabolic pathways, AR, PK, and PDK/PDH, were also restored; indexes of oxidative stress and inflammation, NAD+/NADH ratio, and AGEs in the kidneys were mostly significantly preserved after pyruvate treatments. We concluded that oral pyruvate delayed DN progression in db/db mice and the modified Pyr-ORS formula might be an ideal novel therapeutic drink in clinical prevention and treatment of type 2 diabetes and DN.http://dx.doi.org/10.1155/2020/2817972 |
| spellingShingle | Xiao Meng Zhang Hao Deng Jin Dong Tong Yi Zhen Wang Xu Chao Ning Xiu Hong Yang Fang Qiang Zhou Hui Min Jin Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice Journal of Diabetes Research |
| title | Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice |
| title_full | Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice |
| title_fullStr | Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice |
| title_full_unstemmed | Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice |
| title_short | Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice |
| title_sort | pyruvate enriched oral rehydration solution improves glucometabolic disorders in the kidneys of diabetic db db mice |
| url | http://dx.doi.org/10.1155/2020/2817972 |
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