Curcumin-loaded milk-derived sEVs fused with platelet membrane attenuate endothelial senescence and promote spinal cord injury recovery in diabetic mice

Curcumin-loaded milk-derived sEVs fused with platelet membrane attenuate endothelial senescence and promote spinal cord injury recovery in diabetic mice

Spinal cord injury (SCI) causes devastating neurological deficits, and cellular senescence critically contributes to the pathogenesis of various diseases. Notably, endothelial cells (ECs) senescence exerts a pivotal effect on the pathogenesis following SCI. In this study, we found that the number of...

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Main Authors: Yaozhi He, Siyuan Zou, Jiawei Wang, Wenbin Zhang, Sheng Lu, Mengxian Jia, Yumin Wu, Xiaowu Lin, Ziwei Fan, Qishun Liang, Yizhe Sheng, Qichuan Zhuge, Bi Chen, Minyu Zhu, Honglin Teng
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Diabetes
Spinal cord injury
Milk-derived sEVs
Platelet membrane
Endothelial cell senescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425006064
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