Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction
Abstract Obstructive sleep apnea (OSA) significantly impacts cardiovascular health in post-menopausal females. Given that cardiovascular and cerebrovascular diseases are tightly linked, OSA-mediated impacts on cerebrovascular function and Alzheimer’s Disease (AD) risk are also likely more manifest i...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | npj Women's Health |
| Online Access: | https://doi.org/10.1038/s44294-025-00076-w |
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| _version_ | 1849729032398045184 |
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| author | Ian M. Greenlund Jill N. Barnes Sarah E. Baker Virend K. Somers Joshua M. Bock |
| author_facet | Ian M. Greenlund Jill N. Barnes Sarah E. Baker Virend K. Somers Joshua M. Bock |
| author_sort | Ian M. Greenlund |
| collection | DOAJ |
| description | Abstract Obstructive sleep apnea (OSA) significantly impacts cardiovascular health in post-menopausal females. Given that cardiovascular and cerebrovascular diseases are tightly linked, OSA-mediated impacts on cerebrovascular function and Alzheimer’s Disease (AD) risk are also likely more manifest in females. This review will: summarize sex differences in cerebrovascular function, review the vascular hypothesis of AD, characterize sex differences in the OSA phenotype and implications for cerebrovascular control, and highlight OSA-mediated AD risk. |
| format | Article |
| id | doaj-art-19f7ada34f8d477a90a5cffaffe353f1 |
| institution | DOAJ |
| issn | 2948-1716 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Women's Health |
| spelling | doaj-art-19f7ada34f8d477a90a5cffaffe353f12025-08-20T03:09:20ZengNature Portfolionpj Women's Health2948-17162025-05-01311710.1038/s44294-025-00076-wSex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunctionIan M. Greenlund0Jill N. Barnes1Sarah E. Baker2Virend K. Somers3Joshua M. Bock4Department of Cardiovascular Medicine, Mayo ClinicBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-MadisonDepartment of Anesthesiology & Perioperative Medicine, Mayo ClinicDepartment of Cardiovascular Medicine, Mayo ClinicDepartment of Cardiovascular Medicine, Mayo ClinicAbstract Obstructive sleep apnea (OSA) significantly impacts cardiovascular health in post-menopausal females. Given that cardiovascular and cerebrovascular diseases are tightly linked, OSA-mediated impacts on cerebrovascular function and Alzheimer’s Disease (AD) risk are also likely more manifest in females. This review will: summarize sex differences in cerebrovascular function, review the vascular hypothesis of AD, characterize sex differences in the OSA phenotype and implications for cerebrovascular control, and highlight OSA-mediated AD risk.https://doi.org/10.1038/s44294-025-00076-w |
| spellingShingle | Ian M. Greenlund Jill N. Barnes Sarah E. Baker Virend K. Somers Joshua M. Bock Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction npj Women's Health |
| title | Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction |
| title_full | Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction |
| title_fullStr | Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction |
| title_full_unstemmed | Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction |
| title_short | Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction |
| title_sort | sex differences in sleep apnea and alzheimer s disease role of cerebrovascular dysfunction |
| url | https://doi.org/10.1038/s44294-025-00076-w |
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