Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke
BackgroundWhite matter hyperintensity (WMH) and brain atrophy, as imaging marker of cerebral small-vessel diseases (CSVD), have a high prevalence and strong prognostic value in stroke. We aimed to explore the association between lymphocyte count, a maker of inflammation, and WMH and brain atrophy in...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1492078/full |
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| author | Chenchen Liu Dai Shi Xiaoqiong Ni Shoujiang You Shoujiang You Xiaofen Wu Sheng Zhuang Sheng Zhuang Wu Cai Liang Xu Liang Xu |
| author_facet | Chenchen Liu Dai Shi Xiaoqiong Ni Shoujiang You Shoujiang You Xiaofen Wu Sheng Zhuang Sheng Zhuang Wu Cai Liang Xu Liang Xu |
| author_sort | Chenchen Liu |
| collection | DOAJ |
| description | BackgroundWhite matter hyperintensity (WMH) and brain atrophy, as imaging marker of cerebral small-vessel diseases (CSVD), have a high prevalence and strong prognostic value in stroke. We aimed to explore the association between lymphocyte count, a maker of inflammation, and WMH and brain atrophy in patients with acute ischemic stroke (AIS).MethodsA total of 727 AIS patients with lymphocyte count and brain magnetic resonance imaging data were enrolled. Participants were divided into four groups according to the quartiles of baseline lymphocyte counts. WMH is frequently divided into periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH). WMH was defined as Fazekas scale score ≥ 3; PVH was defined as periventricular Fazekas scale ≥2; DWMH was defined as deep Fazekas scale ≥2. Brain atrophy was defined as global cortical atrophy score ≥ 1. Multivariable logistic regression models were used to assess the association between lymphocyte count and WMH and brain atrophy.ResultsAmong 727 AIS, 517 (71.1%), 442 (60.8%), 459 (63.1%), 583 (80.2%) had WMH, PVH, DWMH and brain atrophy, respectively. After adjustment for potential covariates, the highest quartiles of lymphocyte counts were significantly associated with lower risk of WMH (adjusted odds ratio [aOR] 0.57, 95% confidence intervals [CI] 0.32–0.99), PVH (aOR 0.52, 95% CI 0.31–0.87), DWMH (aOR 0.53 95% CI 0.32–0.90) as well as brain atrophy (aOR 0.46, 95% CI 0.23–0.92) compared with the lowest quartiles of lymphocyte counts, respectively. Furthermore, a notable inverse association was observed between continuous lymphocyte counts and WMH, PVH, DWMH, and brain atrophy. Additionally, we found that the inverse association between baseline lymphocyte count and WMH was significant only in individuals with mild stroke.ConclusionIn patients with AIS, there was an independent and inverse association between the baseline lymphocyte count and both WMH and brain atrophy. |
| format | Article |
| id | doaj-art-19f4a382ab074cfab94134ae05041ae7 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-19f4a382ab074cfab94134ae05041ae72025-01-08T06:11:58ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011610.3389/fnagi.2024.14920781492078Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic strokeChenchen Liu0Dai Shi1Xiaoqiong Ni2Shoujiang You3Shoujiang You4Xiaofen Wu5Sheng Zhuang6Sheng Zhuang7Wu Cai8Liang Xu9Liang Xu10Department of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaBackgroundWhite matter hyperintensity (WMH) and brain atrophy, as imaging marker of cerebral small-vessel diseases (CSVD), have a high prevalence and strong prognostic value in stroke. We aimed to explore the association between lymphocyte count, a maker of inflammation, and WMH and brain atrophy in patients with acute ischemic stroke (AIS).MethodsA total of 727 AIS patients with lymphocyte count and brain magnetic resonance imaging data were enrolled. Participants were divided into four groups according to the quartiles of baseline lymphocyte counts. WMH is frequently divided into periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH). WMH was defined as Fazekas scale score ≥ 3; PVH was defined as periventricular Fazekas scale ≥2; DWMH was defined as deep Fazekas scale ≥2. Brain atrophy was defined as global cortical atrophy score ≥ 1. Multivariable logistic regression models were used to assess the association between lymphocyte count and WMH and brain atrophy.ResultsAmong 727 AIS, 517 (71.1%), 442 (60.8%), 459 (63.1%), 583 (80.2%) had WMH, PVH, DWMH and brain atrophy, respectively. After adjustment for potential covariates, the highest quartiles of lymphocyte counts were significantly associated with lower risk of WMH (adjusted odds ratio [aOR] 0.57, 95% confidence intervals [CI] 0.32–0.99), PVH (aOR 0.52, 95% CI 0.31–0.87), DWMH (aOR 0.53 95% CI 0.32–0.90) as well as brain atrophy (aOR 0.46, 95% CI 0.23–0.92) compared with the lowest quartiles of lymphocyte counts, respectively. Furthermore, a notable inverse association was observed between continuous lymphocyte counts and WMH, PVH, DWMH, and brain atrophy. Additionally, we found that the inverse association between baseline lymphocyte count and WMH was significant only in individuals with mild stroke.ConclusionIn patients with AIS, there was an independent and inverse association between the baseline lymphocyte count and both WMH and brain atrophy.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1492078/fulllymphocyte countwhite matter hyperintensitybrain atrophyischemic strokeassociation |
| spellingShingle | Chenchen Liu Dai Shi Xiaoqiong Ni Shoujiang You Shoujiang You Xiaofen Wu Sheng Zhuang Sheng Zhuang Wu Cai Liang Xu Liang Xu Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke Frontiers in Aging Neuroscience lymphocyte count white matter hyperintensity brain atrophy ischemic stroke association |
| title | Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke |
| title_full | Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke |
| title_fullStr | Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke |
| title_full_unstemmed | Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke |
| title_short | Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke |
| title_sort | correlations among lymphocyte count white matter hyperintensity and brain atrophy in patients with ischemic stroke |
| topic | lymphocyte count white matter hyperintensity brain atrophy ischemic stroke association |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1492078/full |
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