Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria
Hua Hao, Hui Geng, Mao Ma Physical Examination Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Mao Ma, Email mamaoxj@163.comObjective: To explore the association between triglyceride glucose index (TyG) and hypertension un...
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Dove Medical Press
2025-01-01
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| Series: | International Journal of General Medicine |
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| author | Hao H Geng H Ma M |
| author_facet | Hao H Geng H Ma M |
| author_sort | Hao H |
| collection | DOAJ |
| description | Hua Hao, Hui Geng, Mao Ma Physical Examination Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Mao Ma, Email mamaoxj@163.comObjective: To explore the association between triglyceride glucose index (TyG) and hypertension under different diagnostic thresholds.Methods: This study analyzed data from routine occupational health examinations conducted at the First Affiliated Hospital of Xi’an Jiaotong University in 2019. TyG and TyG-BMI, indicators of insulin resistance (IR), were calculated using triglyceride (TG), fasting blood glucose (FPG), and body mass index (BMI). Hypertension was defined by thresholds of 140/90 mmHg and 130/80 mmHg. Logistic regression models were employed to investigate the association between TyG and hypertension.Results: Among 4028 subjects, after adjusting for covariates, the risk of hypertension (diagnosed by 140/90 mmHg) was 2.87 times higher (OR=2.87, 95% CI: 2.11– 3.91) in the Q4 group of TyG compared to the Q1 group. Similarly, the risk was 8.03 times higher (OR=8.03, 95% CI: 5.05– 12.75) in the Q4 group of TyG-BMI than in the Q1 group. Furthermore, the risk of hypertension (diagnosed by 130/80 mmHg) was 2.93 times higher (OR=2.93, 95% CI: 2.34– 3.68) in the Q4 group of TyG compared to the Q1 group, and 7.12 times higher (OR=7.12, 95% CI: 5.08– 9.99) in the Q4 group of TyG-BMI than in the Q1 group. The restricted cubic spline further showed a dose-response relationship between TyG/ TyG-BMI and hypertension. In the population with a BMI of 24.0– 27.9 kg/m2, the risk of developing hypertension (diagnosed by 140/90 mmHg) in the Q4 group of TyG was 2.79 times higher (OR=2.79, 95% CI: 1.67– 4.66), while the Q4 group with TyG had a 3.07 times greater risk of hypertension (diagnosed by 130/80 mmHg) than the Q1 group (OR=3.07, 95% CI: 2.05– 4.60).Conclusion: TyG is an independent risk factor for hypertension across different thresholds, showing a clear dose-response relationship. BMI may influence this association, emphasizing the importance of managing insulin resistance early to aid hypertension prevention.Keywords: triglyceride glucose index, hypertension, insulin resistance, body mass index |
| format | Article |
| id | doaj-art-19f499e217314f8593f204367f05f17c |
| institution | Kabale University |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj-art-19f499e217314f8593f204367f05f17c2025-01-07T16:42:40ZengDove Medical PressInternational Journal of General Medicine1178-70742025-01-01Volume 18435398997Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic CriteriaHao HGeng HMa MHua Hao, Hui Geng, Mao Ma Physical Examination Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Mao Ma, Email mamaoxj@163.comObjective: To explore the association between triglyceride glucose index (TyG) and hypertension under different diagnostic thresholds.Methods: This study analyzed data from routine occupational health examinations conducted at the First Affiliated Hospital of Xi’an Jiaotong University in 2019. TyG and TyG-BMI, indicators of insulin resistance (IR), were calculated using triglyceride (TG), fasting blood glucose (FPG), and body mass index (BMI). Hypertension was defined by thresholds of 140/90 mmHg and 130/80 mmHg. Logistic regression models were employed to investigate the association between TyG and hypertension.Results: Among 4028 subjects, after adjusting for covariates, the risk of hypertension (diagnosed by 140/90 mmHg) was 2.87 times higher (OR=2.87, 95% CI: 2.11– 3.91) in the Q4 group of TyG compared to the Q1 group. Similarly, the risk was 8.03 times higher (OR=8.03, 95% CI: 5.05– 12.75) in the Q4 group of TyG-BMI than in the Q1 group. Furthermore, the risk of hypertension (diagnosed by 130/80 mmHg) was 2.93 times higher (OR=2.93, 95% CI: 2.34– 3.68) in the Q4 group of TyG compared to the Q1 group, and 7.12 times higher (OR=7.12, 95% CI: 5.08– 9.99) in the Q4 group of TyG-BMI than in the Q1 group. The restricted cubic spline further showed a dose-response relationship between TyG/ TyG-BMI and hypertension. In the population with a BMI of 24.0– 27.9 kg/m2, the risk of developing hypertension (diagnosed by 140/90 mmHg) in the Q4 group of TyG was 2.79 times higher (OR=2.79, 95% CI: 1.67– 4.66), while the Q4 group with TyG had a 3.07 times greater risk of hypertension (diagnosed by 130/80 mmHg) than the Q1 group (OR=3.07, 95% CI: 2.05– 4.60).Conclusion: TyG is an independent risk factor for hypertension across different thresholds, showing a clear dose-response relationship. BMI may influence this association, emphasizing the importance of managing insulin resistance early to aid hypertension prevention.Keywords: triglyceride glucose index, hypertension, insulin resistance, body mass indexhttps://www.dovepress.com/association-between-triglyceride-glucose-index-and-hypertension-accord-peer-reviewed-fulltext-article-IJGMtriglyceride glucose indexhypertensioninsulin resistancebody mass index |
| spellingShingle | Hao H Geng H Ma M Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria International Journal of General Medicine triglyceride glucose index hypertension insulin resistance body mass index |
| title | Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria |
| title_full | Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria |
| title_fullStr | Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria |
| title_full_unstemmed | Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria |
| title_short | Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria |
| title_sort | association between triglyceride glucose index and hypertension according to different diagnostic criteria |
| topic | triglyceride glucose index hypertension insulin resistance body mass index |
| url | https://www.dovepress.com/association-between-triglyceride-glucose-index-and-hypertension-accord-peer-reviewed-fulltext-article-IJGM |
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