Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammation
Chronic inflammation develops when the immune system is unable to clear a persistent insult. Unresolved chronic inflammation leads to immunosuppression to maintain the internal homeostatic conditions, which is mediated primarily by myeloid-derived suppressor cells (MDSCs). Toll-like receptors 2 (TLR...
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| Format: | Article |
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Termedia Publishing House
2022-02-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/Pam2-lipopeptides-enhance-the-immunosuppressive-activity-of-monocytic-myeloid-derived-suppressor-cells-by-STAT3-signal-in-chronic-inflammation,10,46311,1,1.html |
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| author | Xiaoxia Zhan Xiaobing Jiang Qiuying He Liangyin Zhong Yichong Wang Yulan Huang Shitong He Junli Sheng Jianwei Liao Zhijie Zeng Shengfeng Hu |
| author_facet | Xiaoxia Zhan Xiaobing Jiang Qiuying He Liangyin Zhong Yichong Wang Yulan Huang Shitong He Junli Sheng Jianwei Liao Zhijie Zeng Shengfeng Hu |
| author_sort | Xiaoxia Zhan |
| collection | DOAJ |
| description | Chronic inflammation develops when the immune system is unable to clear a persistent insult. Unresolved chronic inflammation leads to immunosuppression to maintain the internal homeostatic conditions, which is mediated primarily by myeloid-derived suppressor cells (MDSCs). Toll-like receptors 2 (TLR2) has an important role in chronic inflammation and can be activated by a vast number and diversity of TLR2 ligands, for example Pam 2 CSK4. However, the regulatory effect of TLR2 signaling on MDSCs in chronic inflammation remains controversial. This study demonstrated that heat-killed Mycobacterium bovis BCG-induced pathology-free chronic inflammation triggered suppressive monocytic MDSCs (M-MDSCs) that expressed TLR2. Activation of TLR2 signaling by Pam 2 CSK4 treatment enhanced immunosuppression of M-MDSCs by upregulating inducible nitric oxide synthase (iNOS) activity and nitric oxide (NO) production partly through signal transducer and activator of transcription 3 (STAT3) activation. Thus, TLR2 has a fundamental role in promoting the MDSC-mediated immunosuppressive environment during chronic inflammation and might represent a potentially therapeutic target in chronic inflammation disease. |
| format | Article |
| id | doaj-art-19f01d6b102c4b33b4e32379262bcccc |
| institution | OA Journals |
| issn | 1426-3912 1644-4124 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj-art-19f01d6b102c4b33b4e32379262bcccc2025-08-20T02:09:25ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242022-02-01471304010.5114/ceji.2022.11308646311Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammationXiaoxia ZhanXiaobing JiangQiuying HeLiangyin ZhongYichong WangYulan HuangShitong HeJunli ShengJianwei LiaoZhijie ZengShengfeng HuChronic inflammation develops when the immune system is unable to clear a persistent insult. Unresolved chronic inflammation leads to immunosuppression to maintain the internal homeostatic conditions, which is mediated primarily by myeloid-derived suppressor cells (MDSCs). Toll-like receptors 2 (TLR2) has an important role in chronic inflammation and can be activated by a vast number and diversity of TLR2 ligands, for example Pam 2 CSK4. However, the regulatory effect of TLR2 signaling on MDSCs in chronic inflammation remains controversial. This study demonstrated that heat-killed Mycobacterium bovis BCG-induced pathology-free chronic inflammation triggered suppressive monocytic MDSCs (M-MDSCs) that expressed TLR2. Activation of TLR2 signaling by Pam 2 CSK4 treatment enhanced immunosuppression of M-MDSCs by upregulating inducible nitric oxide synthase (iNOS) activity and nitric oxide (NO) production partly through signal transducer and activator of transcription 3 (STAT3) activation. Thus, TLR2 has a fundamental role in promoting the MDSC-mediated immunosuppressive environment during chronic inflammation and might represent a potentially therapeutic target in chronic inflammation disease.https://www.termedia.pl/Pam2-lipopeptides-enhance-the-immunosuppressive-activity-of-monocytic-myeloid-derived-suppressor-cells-by-STAT3-signal-in-chronic-inflammation,10,46311,1,1.htmltoll-like receptor 2 (tlr2) myeloid-derived suppressor cells (mdscs) monocytic mdscs (m-mdscs) signal transducer and activator of transcription 3 (stat3) inducible no synthase (inos/nos2) nitric oxide (no) chronic inflammation. |
| spellingShingle | Xiaoxia Zhan Xiaobing Jiang Qiuying He Liangyin Zhong Yichong Wang Yulan Huang Shitong He Junli Sheng Jianwei Liao Zhijie Zeng Shengfeng Hu Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammation Central European Journal of Immunology toll-like receptor 2 (tlr2) myeloid-derived suppressor cells (mdscs) monocytic mdscs (m-mdscs) signal transducer and activator of transcription 3 (stat3) inducible no synthase (inos/nos2) nitric oxide (no) chronic inflammation. |
| title | Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammation |
| title_full | Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammation |
| title_fullStr | Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammation |
| title_full_unstemmed | Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammation |
| title_short | Pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid-derived suppressor cells by STAT3 signal in chronic inflammation |
| title_sort | pam2 lipopeptides enhance the immunosuppressive activity of monocytic myeloid derived suppressor cells by stat3 signal in chronic inflammation |
| topic | toll-like receptor 2 (tlr2) myeloid-derived suppressor cells (mdscs) monocytic mdscs (m-mdscs) signal transducer and activator of transcription 3 (stat3) inducible no synthase (inos/nos2) nitric oxide (no) chronic inflammation. |
| url | https://www.termedia.pl/Pam2-lipopeptides-enhance-the-immunosuppressive-activity-of-monocytic-myeloid-derived-suppressor-cells-by-STAT3-signal-in-chronic-inflammation,10,46311,1,1.html |
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