Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis
Abstract Background Inadequate medication knowledge and medication nonadherence by patients are considered an issue in healthcare, as they can lead to negative outcomes, such as therapeutic failures and hospitalization. Even though drug dispensing, which has pharmacist counseling as a core element,...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Health Services Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12913-024-12074-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571841358594048 |
|---|---|
| author | Elizabete Priscila Costa Santana Haidelucia Rodrigues Vieira Javarini Dyego Carlos Souza Anacleto de Araújo Sabrina Cerqueira-Santos Tiago Marques Reis Genival Araujo dos Santos-Junior Kérilin Stancine Santos Rocha |
| author_facet | Elizabete Priscila Costa Santana Haidelucia Rodrigues Vieira Javarini Dyego Carlos Souza Anacleto de Araújo Sabrina Cerqueira-Santos Tiago Marques Reis Genival Araujo dos Santos-Junior Kérilin Stancine Santos Rocha |
| author_sort | Elizabete Priscila Costa Santana |
| collection | DOAJ |
| description | Abstract Background Inadequate medication knowledge and medication nonadherence by patients are considered an issue in healthcare, as they can lead to negative outcomes, such as therapeutic failures and hospitalization. Even though drug dispensing, which has pharmacist counseling as a core element, is a service traditionally performed by pharmacists, there is still no evidence about the influence of this service on these health outcomes. Objective To evaluate the influence of drug dispensing on patients’ medication knowledge and medication adherence. Methods A systematic review was conducted in which a literature search was performed in the PubMed/Medline, Biblioteca Virtual da Saúde, Web of Science, and Embase databases, as well as in gray literature. Two reviewers read the titles, abstracts and complete texts according to the eligibility criteria and extracted the data from the included articles. Original studies—of any design—evaluating the influence of drug dispensing on patients' medication knowledge and/or adherence in community pharmacies were included. The methodological quality was assessed through the tools provided by the JBI Institute. The data was analyzed through qualitative synthesis and a meta-analysis was conducted for randomized controlled trials which used the outcome of medication adherence using the RStudio version 4.3.3 program. Results A total of 7,590 studies were identified in the initial search, of which 11 articles met the eligibility criteria and were included in this systematic review. The studies were published in Africa, Latin America, Asia, Europe and Australia. Most of the studies were interventional (n = 7). Four studies evaluated the influence of drug dispensing on the patient’s medication knowledge, and all showed that knowledge increased after dispensing. Eight studies evaluated the influence of dispensing on medication adherence. Three studies were included in the meta-analysis, which showed moderate heterogeneity (I2 = 44%, p = 0.17). The results indicated that there was no statistically significant difference in medication adherence post-dispensing (RR: 1.19; 95%CI 0.99 to 1.43, p = 0.07). Six studies met more than 70% of the quality assessment criteria. Conclusion This systematic review demonstrated that patient’s medication knowledge can be increased through drug dispensing. However, the meta-analysis indicated that drug dispensing does not have an impact on medication adherence. Our findings can support evidence-based decisions, guiding the planning and development of public policies and interventions which improve drug dispensing for patients, families, and communities. |
| format | Article |
| id | doaj-art-19ef243680a848b1b31bf40937553264 |
| institution | Kabale University |
| issn | 1472-6963 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Health Services Research |
| spelling | doaj-art-19ef243680a848b1b31bf409375532642025-02-02T12:14:32ZengBMCBMC Health Services Research1472-69632025-01-0125111710.1186/s12913-024-12074-wDoes drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysisElizabete Priscila Costa Santana0Haidelucia Rodrigues Vieira Javarini1Dyego Carlos Souza Anacleto de Araújo2Sabrina Cerqueira-Santos3Tiago Marques Reis4Genival Araujo dos Santos-Junior5Kérilin Stancine Santos Rocha6Laboratory of Innovation for Healthcare (Linc), Postgraduate Program in Pharmaceutical Sciences, Federal University of Espírito SantoResearch Group on Implementation of Clinical Pharmacy Services in Brazilian Health System (SUS). Postgraduate Program in Pharmaceutical Assistance (PPGASFAR), Federal University of Espírito SantoLaboratory of Innovation for Healthcare (Linc), Postgraduate Program in Pharmaceutical Sciences, Federal University of Espírito SantoFederal University of Juiz de ForaFederal University of Alfenas (UNIFAL)Research Group on Implementation of Clinical Pharmacy Services in Brazilian Health System (SUS). Postgraduate Program in Pharmaceutical Assistance (PPGASFAR), Federal University of Espírito SantoLaboratory of Innovation for Healthcare (Linc), Postgraduate Program in Pharmaceutical Sciences, Federal University of Espírito SantoAbstract Background Inadequate medication knowledge and medication nonadherence by patients are considered an issue in healthcare, as they can lead to negative outcomes, such as therapeutic failures and hospitalization. Even though drug dispensing, which has pharmacist counseling as a core element, is a service traditionally performed by pharmacists, there is still no evidence about the influence of this service on these health outcomes. Objective To evaluate the influence of drug dispensing on patients’ medication knowledge and medication adherence. Methods A systematic review was conducted in which a literature search was performed in the PubMed/Medline, Biblioteca Virtual da Saúde, Web of Science, and Embase databases, as well as in gray literature. Two reviewers read the titles, abstracts and complete texts according to the eligibility criteria and extracted the data from the included articles. Original studies—of any design—evaluating the influence of drug dispensing on patients' medication knowledge and/or adherence in community pharmacies were included. The methodological quality was assessed through the tools provided by the JBI Institute. The data was analyzed through qualitative synthesis and a meta-analysis was conducted for randomized controlled trials which used the outcome of medication adherence using the RStudio version 4.3.3 program. Results A total of 7,590 studies were identified in the initial search, of which 11 articles met the eligibility criteria and were included in this systematic review. The studies were published in Africa, Latin America, Asia, Europe and Australia. Most of the studies were interventional (n = 7). Four studies evaluated the influence of drug dispensing on the patient’s medication knowledge, and all showed that knowledge increased after dispensing. Eight studies evaluated the influence of dispensing on medication adherence. Three studies were included in the meta-analysis, which showed moderate heterogeneity (I2 = 44%, p = 0.17). The results indicated that there was no statistically significant difference in medication adherence post-dispensing (RR: 1.19; 95%CI 0.99 to 1.43, p = 0.07). Six studies met more than 70% of the quality assessment criteria. Conclusion This systematic review demonstrated that patient’s medication knowledge can be increased through drug dispensing. However, the meta-analysis indicated that drug dispensing does not have an impact on medication adherence. Our findings can support evidence-based decisions, guiding the planning and development of public policies and interventions which improve drug dispensing for patients, families, and communities.https://doi.org/10.1186/s12913-024-12074-wDispensingPatient’s Medication KnowledgeMedication AdherencePharmacist |
| spellingShingle | Elizabete Priscila Costa Santana Haidelucia Rodrigues Vieira Javarini Dyego Carlos Souza Anacleto de Araújo Sabrina Cerqueira-Santos Tiago Marques Reis Genival Araujo dos Santos-Junior Kérilin Stancine Santos Rocha Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis BMC Health Services Research Dispensing Patient’s Medication Knowledge Medication Adherence Pharmacist |
| title | Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis |
| title_full | Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis |
| title_fullStr | Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis |
| title_full_unstemmed | Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis |
| title_short | Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis |
| title_sort | does drug dispensing influence patients medication knowledge and medication adherence a systematic review and meta analysis |
| topic | Dispensing Patient’s Medication Knowledge Medication Adherence Pharmacist |
| url | https://doi.org/10.1186/s12913-024-12074-w |
| work_keys_str_mv | AT elizabetepriscilacostasantana doesdrugdispensinginfluencepatientsmedicationknowledgeandmedicationadherenceasystematicreviewandmetaanalysis AT haideluciarodriguesvieirajavarini doesdrugdispensinginfluencepatientsmedicationknowledgeandmedicationadherenceasystematicreviewandmetaanalysis AT dyegocarlossouzaanacletodearaujo doesdrugdispensinginfluencepatientsmedicationknowledgeandmedicationadherenceasystematicreviewandmetaanalysis AT sabrinacerqueirasantos doesdrugdispensinginfluencepatientsmedicationknowledgeandmedicationadherenceasystematicreviewandmetaanalysis AT tiagomarquesreis doesdrugdispensinginfluencepatientsmedicationknowledgeandmedicationadherenceasystematicreviewandmetaanalysis AT genivalaraujodossantosjunior doesdrugdispensinginfluencepatientsmedicationknowledgeandmedicationadherenceasystematicreviewandmetaanalysis AT kerilinstancinesantosrocha doesdrugdispensinginfluencepatientsmedicationknowledgeandmedicationadherenceasystematicreviewandmetaanalysis |