Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications
Abstract Prostate cancer is an important health concern affecting men. Circular RNAs (circRNAs) play an important molecular biological role in regulating gene expression due to their unique structure. Studies have revealed the involvement of circRNAs in many human diseases. In prostate cancer, circR...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02382-0 |
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| _version_ | 1850238188900057088 |
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| author | Xianping Zheng Ling Song Ce Cao Shoutian Sun |
| author_facet | Xianping Zheng Ling Song Ce Cao Shoutian Sun |
| author_sort | Xianping Zheng |
| collection | DOAJ |
| description | Abstract Prostate cancer is an important health concern affecting men. Circular RNAs (circRNAs) play an important molecular biological role in regulating gene expression due to their unique structure. Studies have revealed the involvement of circRNAs in many human diseases. In prostate cancer, circRNAs can act as oncogenes or tumour suppressor genes and affect cancer cell proliferation, invasion, resistance to chemotherapy and, consequently, disease progression. Accordingly, prostate cancer-related circRNAs are expected to serve as new targets in early clinical diagnosis and targeted therapy, but the various roles of circRNAs in prostate cancer have not been fully elucidated. This article reviews the molecular pathological roles of circRNA in prostate cancer and explores its prospects as a translational medicine in clinical treatment and prognostic evaluation. |
| format | Article |
| id | doaj-art-19ee09a02fd147d98aae999a845d3657 |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-19ee09a02fd147d98aae999a845d36572025-08-20T02:01:30ZengBMCEuropean Journal of Medical Research2047-783X2025-02-013011910.1186/s40001-025-02382-0Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applicationsXianping Zheng0Ling Song1Ce Cao2Shoutian Sun3Intensive Care Unit, Zibo Central HospitalDepartment of Emergency, Zibo Central HospitalDepartment of Gastrointestinal Surgery, Zibo Central HospitalDepartment of Emergency, Zibo Central HospitalAbstract Prostate cancer is an important health concern affecting men. Circular RNAs (circRNAs) play an important molecular biological role in regulating gene expression due to their unique structure. Studies have revealed the involvement of circRNAs in many human diseases. In prostate cancer, circRNAs can act as oncogenes or tumour suppressor genes and affect cancer cell proliferation, invasion, resistance to chemotherapy and, consequently, disease progression. Accordingly, prostate cancer-related circRNAs are expected to serve as new targets in early clinical diagnosis and targeted therapy, but the various roles of circRNAs in prostate cancer have not been fully elucidated. This article reviews the molecular pathological roles of circRNA in prostate cancer and explores its prospects as a translational medicine in clinical treatment and prognostic evaluation.https://doi.org/10.1186/s40001-025-02382-0Prostate cancerCircular RNAsChemotherapy resistanceRadiotherapy resistance |
| spellingShingle | Xianping Zheng Ling Song Ce Cao Shoutian Sun Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications European Journal of Medical Research Prostate cancer Circular RNAs Chemotherapy resistance Radiotherapy resistance |
| title | Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications |
| title_full | Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications |
| title_fullStr | Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications |
| title_full_unstemmed | Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications |
| title_short | Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications |
| title_sort | multiple roles of circular rnas in prostate cancer from the biological basis to potential clinical applications |
| topic | Prostate cancer Circular RNAs Chemotherapy resistance Radiotherapy resistance |
| url | https://doi.org/10.1186/s40001-025-02382-0 |
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