Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma
Abstract Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. In this study, an implantable, modulus‐tunable, and ultrasound‐powered MXene/PVA hydrogel‐based tumor treatment device (UP‐MPH‐TTD), which generates sp...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202309610 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540880431480832 |
|---|---|
| author | Xiaoping Hu Ziyi Qiu Yilin Yang Ting Xu Kai Sheng Weicheng Lu Jingdun Xie Bingzhe Xu |
| author_facet | Xiaoping Hu Ziyi Qiu Yilin Yang Ting Xu Kai Sheng Weicheng Lu Jingdun Xie Bingzhe Xu |
| author_sort | Xiaoping Hu |
| collection | DOAJ |
| description | Abstract Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. In this study, an implantable, modulus‐tunable, and ultrasound‐powered MXene/PVA hydrogel‐based tumor treatment device (UP‐MPH‐TTD), which generates specific electromagnetic alternating fields that disrupt the mitosis of cancer cells without adversely affecting normal neurons is developed. The MXene/PVA hydrogel is used to form a tumor treatment field due to its high biocompatibility, excellent flexibility, and high conductivity, which improves ultrasonic electrical conversion efficiency and significantly reduces the size of the equipment. The implantable UP‐MPH‐TTD is wirelessly ultrasound‐powered, small‐sized, lightweight, and simply structured, significantly boosting therapeutic efficiency and reducing restrictions on patient movement. In vitro and in vivo experiments confirmed the device's therapeutic effect, demonstrating a ≈92% inhibition rate in the growth of clinical tumor cells and a 73% reduction in tumor area in tumor‐bearing mice. The promising results indicate the broad application potential of the device in the treatment and prognostic improvement of GBM. |
| format | Article |
| id | doaj-art-19ed0cdb7c6640ab92742f64e7ab9a78 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-19ed0cdb7c6640ab92742f64e7ab9a782025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202309610Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of GlioblastomaXiaoping Hu0Ziyi Qiu1Yilin Yang2Ting Xu3Kai Sheng4Weicheng Lu5Jingdun Xie6Bingzhe Xu7School of Biomedical Engineering Sun Yat‐sen University No. 135, Xingang Xi Road Guangzhou 510275 P. R. ChinaSchool of Biomedical Engineering Sun Yat‐sen University No. 135, Xingang Xi Road Guangzhou 510275 P. R. ChinaFaculty of Engineering Department of Electrical and Electronic Engineering The University of Hong Kong Pokfulam Hong Kong SAR 999077 P. R. ChinaSchool of Biomedical Engineering Shenzhen Campus of Sun Yat‐sen University No.66, Gongchang Road, Guangming District Shenzhen 518107 P. R. ChinaSchool of Biomedical Engineering Sun Yat‐sen University No. 135, Xingang Xi Road Guangzhou 510275 P. R. ChinaDepartment of Anesthesiology State Key Laboratory of Oncology in Southern China Collaborative Innovation for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou Guangdong 510060 P. R. ChinaDepartment of Anesthesiology State Key Laboratory of Oncology in Southern China Collaborative Innovation for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou Guangdong 510060 P. R. ChinaSchool of Biomedical Engineering Sun Yat‐sen University No. 135, Xingang Xi Road Guangzhou 510275 P. R. ChinaAbstract Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. In this study, an implantable, modulus‐tunable, and ultrasound‐powered MXene/PVA hydrogel‐based tumor treatment device (UP‐MPH‐TTD), which generates specific electromagnetic alternating fields that disrupt the mitosis of cancer cells without adversely affecting normal neurons is developed. The MXene/PVA hydrogel is used to form a tumor treatment field due to its high biocompatibility, excellent flexibility, and high conductivity, which improves ultrasonic electrical conversion efficiency and significantly reduces the size of the equipment. The implantable UP‐MPH‐TTD is wirelessly ultrasound‐powered, small‐sized, lightweight, and simply structured, significantly boosting therapeutic efficiency and reducing restrictions on patient movement. In vitro and in vivo experiments confirmed the device's therapeutic effect, demonstrating a ≈92% inhibition rate in the growth of clinical tumor cells and a 73% reduction in tumor area in tumor‐bearing mice. The promising results indicate the broad application potential of the device in the treatment and prognostic improvement of GBM.https://doi.org/10.1002/advs.202309610glioblastomaMXene/PVA hydrogelTTFultrasound‐powered |
| spellingShingle | Xiaoping Hu Ziyi Qiu Yilin Yang Ting Xu Kai Sheng Weicheng Lu Jingdun Xie Bingzhe Xu Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma Advanced Science glioblastoma MXene/PVA hydrogel TTF ultrasound‐powered |
| title | Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma |
| title_full | Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma |
| title_fullStr | Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma |
| title_full_unstemmed | Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma |
| title_short | Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma |
| title_sort | implantable ultrasound powered mxene pva hydrogel based generator for treatment of glioblastoma |
| topic | glioblastoma MXene/PVA hydrogel TTF ultrasound‐powered |
| url | https://doi.org/10.1002/advs.202309610 |
| work_keys_str_mv | AT xiaopinghu implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma AT ziyiqiu implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma AT yilinyang implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma AT tingxu implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma AT kaisheng implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma AT weichenglu implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma AT jingdunxie implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma AT bingzhexu implantableultrasoundpoweredmxenepvahydrogelbasedgeneratorfortreatmentofglioblastoma |