Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy
Word count of the full article: 4834Diabetic cardiomyopathy (DCM) is defined as myocardial dysfunction in diabetes mellitus (DM) patients independent of coronary artery disease (CAD) or hypertension (HTN). With high morbidity and mortality, DCM poses a significant threat to patient health. Its under...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1618230/full |
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| author | Na Su Na Su Jingxuan Zhao Jingxuan Zhao Weiyi Zhang Weiyi Zhang Xinhuan Zhang Kunna Lu Yan Ma Yan Wang Mingfeng Cao |
| author_facet | Na Su Na Su Jingxuan Zhao Jingxuan Zhao Weiyi Zhang Weiyi Zhang Xinhuan Zhang Kunna Lu Yan Ma Yan Wang Mingfeng Cao |
| author_sort | Na Su |
| collection | DOAJ |
| description | Word count of the full article: 4834Diabetic cardiomyopathy (DCM) is defined as myocardial dysfunction in diabetes mellitus (DM) patients independent of coronary artery disease (CAD) or hypertension (HTN). With high morbidity and mortality, DCM poses a significant threat to patient health. Its underlying pathogenesis remains incompletely elucidated, and the prolonged subclinical phase renders early diagnosis and precise treatment clinically challenging. Thus, identifying viable biomarkers for early diagnosis and intervention has emerged as a research imperative, whereas a systematic DCM diagnostic and therapeutic strategy remains to be established. Our examination revealed that circulating soluble suppression of tumorigenicity 2 (sST2), Cardiotrophin-1 (CT-1), and galectin-3 levels correlate closely with DCM progression stages. Combining Lysyl Oxidase-Like 2 (LOXL2) and Electron Transfer Flavoprotein β Subunit (ETFβ) measurements with ultrasound E/E’ ratio and NT-proBNP enhances diagnostic accuracy. Novel noninvasive markers (e.g., skin autofluorescence) show promise. This article comprehensively evaluates the clinical applications of these molecular markers within DCM’s pathophysiological classification framework. |
| format | Article |
| id | doaj-art-19eb61d7531e406b83076508cff15e7b |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-19eb61d7531e406b83076508cff15e7b2025-08-20T04:02:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.16182301618230Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathyNa Su0Na Su1Jingxuan Zhao2Jingxuan Zhao3Weiyi Zhang4Weiyi Zhang5Xinhuan Zhang6Kunna Lu7Yan Ma8Yan Wang9Mingfeng Cao10Graduate School, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaGraduate School, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaGraduate School, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaWord count of the full article: 4834Diabetic cardiomyopathy (DCM) is defined as myocardial dysfunction in diabetes mellitus (DM) patients independent of coronary artery disease (CAD) or hypertension (HTN). With high morbidity and mortality, DCM poses a significant threat to patient health. Its underlying pathogenesis remains incompletely elucidated, and the prolonged subclinical phase renders early diagnosis and precise treatment clinically challenging. Thus, identifying viable biomarkers for early diagnosis and intervention has emerged as a research imperative, whereas a systematic DCM diagnostic and therapeutic strategy remains to be established. Our examination revealed that circulating soluble suppression of tumorigenicity 2 (sST2), Cardiotrophin-1 (CT-1), and galectin-3 levels correlate closely with DCM progression stages. Combining Lysyl Oxidase-Like 2 (LOXL2) and Electron Transfer Flavoprotein β Subunit (ETFβ) measurements with ultrasound E/E’ ratio and NT-proBNP enhances diagnostic accuracy. Novel noninvasive markers (e.g., skin autofluorescence) show promise. This article comprehensively evaluates the clinical applications of these molecular markers within DCM’s pathophysiological classification framework.https://www.frontiersin.org/articles/10.3389/fendo.2025.1618230/fulldiabetic cardiomyopathymolecular markersoxidative stressnon-coding RNAearly diagnosis |
| spellingShingle | Na Su Na Su Jingxuan Zhao Jingxuan Zhao Weiyi Zhang Weiyi Zhang Xinhuan Zhang Kunna Lu Yan Ma Yan Wang Mingfeng Cao Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy Frontiers in Endocrinology diabetic cardiomyopathy molecular markers oxidative stress non-coding RNA early diagnosis |
| title | Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy |
| title_full | Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy |
| title_fullStr | Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy |
| title_full_unstemmed | Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy |
| title_short | Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy |
| title_sort | study of independent diagnostic efficacy and co diagnostic strategies of molecular markers for diabetic cardiomyopathy |
| topic | diabetic cardiomyopathy molecular markers oxidative stress non-coding RNA early diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1618230/full |
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