The role of tumor-associated macrophages in HPV induced cervical cancer
Human papillomavirus (HPV), a double-stranded DNA virus linked to various malignancies, poses a significant global public health challenge. In cervical cancer, persistent infection with high-risk HPV genotypes, particularly HPV-16 and HPV-18, initiates immune evasion mechanisms within the tumor micr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586806/full |
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| author | Zeping Chen Binzhu Zhao |
| author_facet | Zeping Chen Binzhu Zhao |
| author_sort | Zeping Chen |
| collection | DOAJ |
| description | Human papillomavirus (HPV), a double-stranded DNA virus linked to various malignancies, poses a significant global public health challenge. In cervical cancer, persistent infection with high-risk HPV genotypes, particularly HPV-16 and HPV-18, initiates immune evasion mechanisms within the tumor microenvironment. The polarization of tumor-associated macrophages (TAMs) from M1 to M2 phenotypes promotes cervical carcinogenesis, metastasis, and therapeutic resistance via establishing an immunosuppressive microenvironment. This review provides a comprehensive overview of HPV-induced immune evasion pathways, including MHC downregulation, T-cell impairment, regulatory T cell induction, and cGAS-STING pathway inhibition. Furthermore, describe the pivotal role of TAMs in cervical cancer progression, focusing on their phenotypic plasticity, pro-tumoral functions, and potential as therapeutic targets. By elucidating these cellular and molecular dynamics, this review aims to support advanced research. Targeting TAM polarization through immunotherapies and nanomedicine-based strategies represents a promising strategy for enhancing patient outcomes. |
| format | Article |
| id | doaj-art-19e81777b89a4d9fa21053cee7c3d859 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-19e81777b89a4d9fa21053cee7c3d8592025-08-20T02:25:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15868061586806The role of tumor-associated macrophages in HPV induced cervical cancerZeping ChenBinzhu ZhaoHuman papillomavirus (HPV), a double-stranded DNA virus linked to various malignancies, poses a significant global public health challenge. In cervical cancer, persistent infection with high-risk HPV genotypes, particularly HPV-16 and HPV-18, initiates immune evasion mechanisms within the tumor microenvironment. The polarization of tumor-associated macrophages (TAMs) from M1 to M2 phenotypes promotes cervical carcinogenesis, metastasis, and therapeutic resistance via establishing an immunosuppressive microenvironment. This review provides a comprehensive overview of HPV-induced immune evasion pathways, including MHC downregulation, T-cell impairment, regulatory T cell induction, and cGAS-STING pathway inhibition. Furthermore, describe the pivotal role of TAMs in cervical cancer progression, focusing on their phenotypic plasticity, pro-tumoral functions, and potential as therapeutic targets. By elucidating these cellular and molecular dynamics, this review aims to support advanced research. Targeting TAM polarization through immunotherapies and nanomedicine-based strategies represents a promising strategy for enhancing patient outcomes.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586806/fullmacrophagecervical cancerHPVimmune responseTAM recruitmentvaccine |
| spellingShingle | Zeping Chen Binzhu Zhao The role of tumor-associated macrophages in HPV induced cervical cancer Frontiers in Immunology macrophage cervical cancer HPV immune response TAM recruitment vaccine |
| title | The role of tumor-associated macrophages in HPV induced cervical cancer |
| title_full | The role of tumor-associated macrophages in HPV induced cervical cancer |
| title_fullStr | The role of tumor-associated macrophages in HPV induced cervical cancer |
| title_full_unstemmed | The role of tumor-associated macrophages in HPV induced cervical cancer |
| title_short | The role of tumor-associated macrophages in HPV induced cervical cancer |
| title_sort | role of tumor associated macrophages in hpv induced cervical cancer |
| topic | macrophage cervical cancer HPV immune response TAM recruitment vaccine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586806/full |
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