Protracted HBsAg-aemia in a Patient with Acute Hepatitis B
Aim. This clinical observation was aimed at analysing the course of the disease in a patient with a protracted persistence of HBsAg and HBV DNA in the blood in the outcome of acute hepatitis B and the possible formation of a latent HBV infection in the phase of clinical recovery.General findings. We...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-11-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/269 |
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| _version_ | 1823860108323454976 |
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| author | K. R. Dudina O. O. Znoyko |
| author_facet | K. R. Dudina O. O. Znoyko |
| author_sort | K. R. Dudina |
| collection | DOAJ |
| description | Aim. This clinical observation was aimed at analysing the course of the disease in a patient with a protracted persistence of HBsAg and HBV DNA in the blood in the outcome of acute hepatitis B and the possible formation of a latent HBV infection in the phase of clinical recovery.General findings. We carried out a 31-month observation study of a patient suffering from acute hepatitis B. Subsequently, we performed a dynamic assessment of the viral kinetics and qualitative and quantitative assessment of HBsAg in the blood using highly sensitive analytical methods. These methods allowed a protracted persistence of HBV DNA in the blood and a late seroconversion of HBsAg/anti-HBs to be revealed.Conclusion. The described clinical case demonstrates the possibility of an atypically protracted persistence of HBsAg in the outcome of acute hepatitis B, which is followed by a clinical and laboratory picture of recovery and the formation of latent chronic HBV infection, as an example of the 5th phase of chronic HBV infection (HBsAg-negative), according to a new classification, reflected in the clinical guidelines for the treatment of hepatitis B (EASL 2017). |
| format | Article |
| id | doaj-art-19e7bb0df107452cb43bdc084e9ad1ab |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-11-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-19e7bb0df107452cb43bdc084e9ad1ab2025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-11-0128512613310.22416/1382-4376-2018-28-5-126-133268Protracted HBsAg-aemia in a Patient with Acute Hepatitis BK. R. Dudina0O. O. Znoyko1A.I. Evdokimov Moscow State University of Medicine and Dentistry, Department of Infectious Diseases and Epidemiology.A.I. Evdokimov Moscow State University of Medicine and Dentistry, Department of Infectious Diseases and Epidemiology.Aim. This clinical observation was aimed at analysing the course of the disease in a patient with a protracted persistence of HBsAg and HBV DNA in the blood in the outcome of acute hepatitis B and the possible formation of a latent HBV infection in the phase of clinical recovery.General findings. We carried out a 31-month observation study of a patient suffering from acute hepatitis B. Subsequently, we performed a dynamic assessment of the viral kinetics and qualitative and quantitative assessment of HBsAg in the blood using highly sensitive analytical methods. These methods allowed a protracted persistence of HBV DNA in the blood and a late seroconversion of HBsAg/anti-HBs to be revealed.Conclusion. The described clinical case demonstrates the possibility of an atypically protracted persistence of HBsAg in the outcome of acute hepatitis B, which is followed by a clinical and laboratory picture of recovery and the formation of latent chronic HBV infection, as an example of the 5th phase of chronic HBV infection (HBsAg-negative), according to a new classification, reflected in the clinical guidelines for the treatment of hepatitis B (EASL 2017).https://www.gastro-j.ru/jour/article/view/269acute hepatitis bhbsag-aemia |
| spellingShingle | K. R. Dudina O. O. Znoyko Protracted HBsAg-aemia in a Patient with Acute Hepatitis B Российский журнал гастроэнтерологии, гепатологии, колопроктологии acute hepatitis b hbsag-aemia |
| title | Protracted HBsAg-aemia in a Patient with Acute Hepatitis B |
| title_full | Protracted HBsAg-aemia in a Patient with Acute Hepatitis B |
| title_fullStr | Protracted HBsAg-aemia in a Patient with Acute Hepatitis B |
| title_full_unstemmed | Protracted HBsAg-aemia in a Patient with Acute Hepatitis B |
| title_short | Protracted HBsAg-aemia in a Patient with Acute Hepatitis B |
| title_sort | protracted hbsag aemia in a patient with acute hepatitis b |
| topic | acute hepatitis b hbsag-aemia |
| url | https://www.gastro-j.ru/jour/article/view/269 |
| work_keys_str_mv | AT krdudina protractedhbsagaemiainapatientwithacutehepatitisb AT ooznoyko protractedhbsagaemiainapatientwithacutehepatitisb |