GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states

GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states

Abstract G-protein coupled receptors (GPCRs), the largest family of membrane proteins in human body, involve a great variety of biological processes and thus have become highly valuable drug targets. By binding with ligands (e.g., drugs), GPCRs switch between active and inactive conformational state...

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Bibliographic Details
Main Authors: Fan Liu, Han Zhou, Xiaonong Li, Liangliang Zhou, Chungong Yu, Haicang Zhang, Dongbo Bu, Xinmiao Liang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Bioinformatics
Subjects:
G-protein coupled receptor
State-specific structure
Binding site
Key residue
Database
Online Access:https://doi.org/10.1186/s12859-024-05962-9
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