Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment
BackgroundIn patients with anorexia nervosa (AN), gastrointestinal (GI) symptoms are common and usually improve during or after nutritional rehabilitation. It is unclear when exactly GI symptoms change in the timecourse of treatment and to which extent. In this study, we analyzed the timecourse of G...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.962837/full |
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| author | Caroline Riedlinger Caroline Riedlinger Nazar Mazurak Nazar Mazurak Norbert Schäffeler Andreas Stengel Andreas Stengel Andreas Stengel Katrin Elisabeth Giel Katrin Elisabeth Giel Stephan Zipfel Stephan Zipfel Paul Enck Paul Enck Isabelle Mack Isabelle Mack |
| author_facet | Caroline Riedlinger Caroline Riedlinger Nazar Mazurak Nazar Mazurak Norbert Schäffeler Andreas Stengel Andreas Stengel Andreas Stengel Katrin Elisabeth Giel Katrin Elisabeth Giel Stephan Zipfel Stephan Zipfel Paul Enck Paul Enck Isabelle Mack Isabelle Mack |
| author_sort | Caroline Riedlinger |
| collection | DOAJ |
| description | BackgroundIn patients with anorexia nervosa (AN), gastrointestinal (GI) symptoms are common and usually improve during or after nutritional rehabilitation. It is unclear when exactly GI symptoms change in the timecourse of treatment and to which extent. In this study, we analyzed the timecourse of GI symptoms and their relation to disease-specific, demographic, anthropometric, and psychological factors in inpatients with AN.MethodsIn weekly intervals, the Gastrointestinal Symptom Rating Scale (GSRS) was completed, and body weight was measured over a mean of 9.5 weeks in inpatients with AN. A total of four self-report questionnaires assessing psychological factors were completed before and after inpatient treatment. Data from 38 inpatients with AN were analyzed using mixed linear models.ResultsAbdominal pain and constipation improved significantly in the timecourse with 0.085 (p = 0.002) and 0.101 (p = 0.004) points per week on the GSRS and were predicted to normalize after 13 (p = 0.002) and 17 (p = 0.004) weeks, respectively. Total GI symptoms tended to normalize after 25 weeks (p = 0.079). Indigestion (borborygmus, abdominal distension, eructation, flatulence) was the most severely pathological symptom at admission and did not improve significantly (p = 0.197). Diarrhea and reflux were, on average, not pathological at admission and remained stable during treatment. In addition to treatment time, the strongest predictors were ED pathology at admission for the development of abdominal pain, constipation, reflux, and total GI symptoms; stress for the development of constipation and total GI symptoms; and depression for constipation.ConclusionsInforming patients with AN about the course of GI symptoms and their improvement during weight rehabilitation may help support compliance during treatment. |
| format | Article |
| id | doaj-art-19e5084d41ef4ccc9eaa65c6f7a41872 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-19e5084d41ef4ccc9eaa65c6f7a418722025-02-11T16:15:13ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-08-011310.3389/fpsyt.2022.962837962837Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatmentCaroline Riedlinger0Caroline Riedlinger1Nazar Mazurak2Nazar Mazurak3Norbert Schäffeler4Andreas Stengel5Andreas Stengel6Andreas Stengel7Katrin Elisabeth Giel8Katrin Elisabeth Giel9Stephan Zipfel10Stephan Zipfel11Paul Enck12Paul Enck13Isabelle Mack14Isabelle Mack15Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), Tübingen, GermanyCharité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, GermanyCentre of Excellence for Eating Disorders (KOMET), Tübingen, GermanyBackgroundIn patients with anorexia nervosa (AN), gastrointestinal (GI) symptoms are common and usually improve during or after nutritional rehabilitation. It is unclear when exactly GI symptoms change in the timecourse of treatment and to which extent. In this study, we analyzed the timecourse of GI symptoms and their relation to disease-specific, demographic, anthropometric, and psychological factors in inpatients with AN.MethodsIn weekly intervals, the Gastrointestinal Symptom Rating Scale (GSRS) was completed, and body weight was measured over a mean of 9.5 weeks in inpatients with AN. A total of four self-report questionnaires assessing psychological factors were completed before and after inpatient treatment. Data from 38 inpatients with AN were analyzed using mixed linear models.ResultsAbdominal pain and constipation improved significantly in the timecourse with 0.085 (p = 0.002) and 0.101 (p = 0.004) points per week on the GSRS and were predicted to normalize after 13 (p = 0.002) and 17 (p = 0.004) weeks, respectively. Total GI symptoms tended to normalize after 25 weeks (p = 0.079). Indigestion (borborygmus, abdominal distension, eructation, flatulence) was the most severely pathological symptom at admission and did not improve significantly (p = 0.197). Diarrhea and reflux were, on average, not pathological at admission and remained stable during treatment. In addition to treatment time, the strongest predictors were ED pathology at admission for the development of abdominal pain, constipation, reflux, and total GI symptoms; stress for the development of constipation and total GI symptoms; and depression for constipation.ConclusionsInforming patients with AN about the course of GI symptoms and their improvement during weight rehabilitation may help support compliance during treatment.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.962837/fullabdominal painanorexia nervosaconstipationeating disordersgastrointestinal complaintsindigestion |
| spellingShingle | Caroline Riedlinger Caroline Riedlinger Nazar Mazurak Nazar Mazurak Norbert Schäffeler Andreas Stengel Andreas Stengel Andreas Stengel Katrin Elisabeth Giel Katrin Elisabeth Giel Stephan Zipfel Stephan Zipfel Paul Enck Paul Enck Isabelle Mack Isabelle Mack Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment Frontiers in Psychiatry abdominal pain anorexia nervosa constipation eating disorders gastrointestinal complaints indigestion |
| title | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
| title_full | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
| title_fullStr | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
| title_full_unstemmed | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
| title_short | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
| title_sort | gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
| topic | abdominal pain anorexia nervosa constipation eating disorders gastrointestinal complaints indigestion |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.962837/full |
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