ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study
Abstract Background The ABO blood group system has shown an association with cardiovascular disease. The susceptibility to CVD is proposed to be partly mediated by dyslipidaemia in non-O individuals. Previous studies are scarce for the RhD blood group, but we recently showed that RhD − young individ...
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BMC
2025-01-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-025-02444-6 |
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| author | Malin Mickelsson Kim Ekblom Kristina Stefansson Per Liv Anders Själander Ulf Näslund Johan Hultdin |
| author_facet | Malin Mickelsson Kim Ekblom Kristina Stefansson Per Liv Anders Själander Ulf Näslund Johan Hultdin |
| author_sort | Malin Mickelsson |
| collection | DOAJ |
| description | Abstract Background The ABO blood group system has shown an association with cardiovascular disease. The susceptibility to CVD is proposed to be partly mediated by dyslipidaemia in non-O individuals. Previous studies are scarce for the RhD blood group, but we recently showed that RhD − young individuals are associated with subclinical atherosclerosis. Hence, we sought to examine whether the ABO blood groups and RhD factor are associated with dyslipidaemia. Methods All participants were part of the VIPVIZA study, including 3532 individuals with available plasma lipid levels. Lipids were assessed as total, LDL, HDL, remnant, non-HDL cholesterol and triglycerides. Information about ABO and RhD was retrieved by linking VIPVIZA with the SCANDAT-3 database, where 85% of VIPVIZA participants were registered. Results For the ABO blood groups, no significant differences in lipid levels between non-O and O individuals were seen. In 40-year-old males, RhD − individuals compared to RhD + had higher levels of non-HDL cholesterol, LDL cholesterol, and remnant cholesterol, with ratios of geometric means of 1.21 (CI95% 1.03; 1.43), 1.20 (1.02; 1.41) and 1.38 (1.00; 1.92), respectively. No differences in lipid levels depending on the RhD blood group were seen in women or the older age groups. Conclusion Our study indicates that younger RhD − men have increased non-HDL, LDL, and remnant cholesterol levels. Thus, the RhD blood group, but not ABO, seems to be associated with dyslipidaemia and may act as a future possible risk marker of cardiovascular disease. Graphical Abstract |
| format | Article |
| id | doaj-art-19e27280856a4bfa9cbe2cc6b08526a5 |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-19e27280856a4bfa9cbe2cc6b08526a52025-01-26T12:50:29ZengBMCLipids in Health and Disease1476-511X2025-01-0124111110.1186/s12944-025-02444-6ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional studyMalin Mickelsson0Kim Ekblom1Kristina Stefansson2Per Liv3Anders Själander4Ulf Näslund5Johan Hultdin6Department of Medical Biosciences, Clinical Chemistry, Umeå UniversityDepartment of Medical Biosciences, Clinical Chemistry, Umeå UniversityDepartment of Medical Biosciences, Clinical Chemistry, Umeå UniversityDepartment of Public Health and Clinical Medicine, Umeå UniversityDepartment of Public Health and Clinical Medicine, Umeå UniversityDepartment of Public Health and Clinical Medicine, Umeå UniversityDepartment of Medical Biosciences, Clinical Chemistry, Umeå UniversityAbstract Background The ABO blood group system has shown an association with cardiovascular disease. The susceptibility to CVD is proposed to be partly mediated by dyslipidaemia in non-O individuals. Previous studies are scarce for the RhD blood group, but we recently showed that RhD − young individuals are associated with subclinical atherosclerosis. Hence, we sought to examine whether the ABO blood groups and RhD factor are associated with dyslipidaemia. Methods All participants were part of the VIPVIZA study, including 3532 individuals with available plasma lipid levels. Lipids were assessed as total, LDL, HDL, remnant, non-HDL cholesterol and triglycerides. Information about ABO and RhD was retrieved by linking VIPVIZA with the SCANDAT-3 database, where 85% of VIPVIZA participants were registered. Results For the ABO blood groups, no significant differences in lipid levels between non-O and O individuals were seen. In 40-year-old males, RhD − individuals compared to RhD + had higher levels of non-HDL cholesterol, LDL cholesterol, and remnant cholesterol, with ratios of geometric means of 1.21 (CI95% 1.03; 1.43), 1.20 (1.02; 1.41) and 1.38 (1.00; 1.92), respectively. No differences in lipid levels depending on the RhD blood group were seen in women or the older age groups. Conclusion Our study indicates that younger RhD − men have increased non-HDL, LDL, and remnant cholesterol levels. Thus, the RhD blood group, but not ABO, seems to be associated with dyslipidaemia and may act as a future possible risk marker of cardiovascular disease. Graphical Abstracthttps://doi.org/10.1186/s12944-025-02444-6ABO Blood-Group systemRhD blood groupAtherosclerosisDyslipidaemia |
| spellingShingle | Malin Mickelsson Kim Ekblom Kristina Stefansson Per Liv Anders Själander Ulf Näslund Johan Hultdin ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study Lipids in Health and Disease ABO Blood-Group system RhD blood group Atherosclerosis Dyslipidaemia |
| title | ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study |
| title_full | ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study |
| title_fullStr | ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study |
| title_full_unstemmed | ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study |
| title_short | ABO and RhD blood groups as contributors to dyslipidaemia – a cross-sectional study |
| title_sort | abo and rhd blood groups as contributors to dyslipidaemia a cross sectional study |
| topic | ABO Blood-Group system RhD blood group Atherosclerosis Dyslipidaemia |
| url | https://doi.org/10.1186/s12944-025-02444-6 |
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