Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique
A slowly progressive Heymann nephritis (SPHN) was induced in three groups of rats by weekly injections of a chemically modified renal tubular antigen in an aqueous medium. A control group of rats received the chemically unmodified version of the antigen in an aqueous solution. One group of SPHN rats...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520600563758 |
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| author | Arpad Z. Barabas Chad D. Cole Arpad D. Barabas Aron N. Barabas Rene Lafreniere |
| author_facet | Arpad Z. Barabas Chad D. Cole Arpad D. Barabas Aron N. Barabas Rene Lafreniere |
| author_sort | Arpad Z. Barabas |
| collection | DOAJ |
| description | A slowly progressive Heymann nephritis (SPHN) was induced in three groups of rats by weekly injections of a chemically modified renal tubular antigen in an aqueous medium. A control group of rats received the chemically unmodified version of the antigen in an aqueous solution. One group of SPHN rats were pre- and post-treated with weekly injections of IC made up of rKF3 and rarKF3 IgM antibody at antigen excess (MIC) (immune complexes [ICs] containing sonicated ultracentrifuged [u/c] rat kidney fraction 3 [rKF3] antigen and IgM antibodies specific against the antigen, at slight antigen excess). One group of SPHN rats were post-treated with MIC 3 weeks after the induction of the disease and one group of SPHN animals received no treatment. The control group of rats received pre- and post-treatment with sonicated u/c rKF3. |
| format | Article |
| id | doaj-art-19e02dfd78ad42929deddfd81ad11ba0 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-19e02dfd78ad42929deddfd81ad11ba02025-08-20T02:01:58ZengWileyClinical and Developmental Immunology1740-25221740-25302006-01-01131172410.1080/17402520600563758Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination TechniqueArpad Z. Barabas0Chad D. Cole1Arpad D. Barabas2Aron N. Barabas3Rene Lafreniere4Department of Surgery, University of Calgary, Health Sciences Centre, Calgary, Alberta, CanadaDepartment of Neurosurgery, University of Utah, Salt Lake City, Utah, USADepartment of Surgery, University of Calgary, Health Sciences Centre, Calgary, Alberta, CanadaDepartment of Surgery, University of Calgary, Health Sciences Centre, Calgary, Alberta, CanadaDepartment of Surgery, University of Calgary, Health Sciences Centre, Calgary, Alberta, CanadaA slowly progressive Heymann nephritis (SPHN) was induced in three groups of rats by weekly injections of a chemically modified renal tubular antigen in an aqueous medium. A control group of rats received the chemically unmodified version of the antigen in an aqueous solution. One group of SPHN rats were pre- and post-treated with weekly injections of IC made up of rKF3 and rarKF3 IgM antibody at antigen excess (MIC) (immune complexes [ICs] containing sonicated ultracentrifuged [u/c] rat kidney fraction 3 [rKF3] antigen and IgM antibodies specific against the antigen, at slight antigen excess). One group of SPHN rats were post-treated with MIC 3 weeks after the induction of the disease and one group of SPHN animals received no treatment. The control group of rats received pre- and post-treatment with sonicated u/c rKF3.http://dx.doi.org/10.1080/17402520600563758 |
| spellingShingle | Arpad Z. Barabas Chad D. Cole Arpad D. Barabas Aron N. Barabas Rene Lafreniere Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique Clinical and Developmental Immunology |
| title | Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique |
| title_full | Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique |
| title_fullStr | Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique |
| title_full_unstemmed | Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique |
| title_short | Reduced Incidence of Slowly Progressive Heymann Nephritis in Rats Immunized With a Modified Vaccination Technique |
| title_sort | reduced incidence of slowly progressive heymann nephritis in rats immunized with a modified vaccination technique |
| url | http://dx.doi.org/10.1080/17402520600563758 |
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