Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. The positive action of the insulin-sensitizing t...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/PPAR/2006/73986 |
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| _version_ | 1832551589452185600 |
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| author | Pascal Froment Philippe Touraine |
| author_facet | Pascal Froment Philippe Touraine |
| author_sort | Pascal Froment |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. The positive action of the insulin-sensitizing treatments could be explained by a decrease in the peripheral insulin resistance but also by a direct action at the ovarian level. We report in this review different hypotheses of thiazolidinediones actions to improve PCOS (steroid secretion by ovarian cells ; insulin sensitivity in muscle and adipocyte and fat redistribution). |
| format | Article |
| id | doaj-art-19dff30c10464ad6b075163dcc212ab0 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-19dff30c10464ad6b075163dcc212ab02025-02-03T06:01:05ZengWileyPPAR Research1687-47571687-47652006-01-01200610.1155/PPAR/2006/7398673986Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS)Pascal Froment0Philippe Touraine1INSERM Unité 418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 Rue Soeur Bouvier, Lyon 69322, FranceDepartment of Endocrinology and Reproductive Medicine, GH Pitié-Salpêtrière, 47‐83 Boulevard de l'Hôpital, Paris Cedex 13 75651, FrancePolycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. The positive action of the insulin-sensitizing treatments could be explained by a decrease in the peripheral insulin resistance but also by a direct action at the ovarian level. We report in this review different hypotheses of thiazolidinediones actions to improve PCOS (steroid secretion by ovarian cells ; insulin sensitivity in muscle and adipocyte and fat redistribution).http://dx.doi.org/10.1155/PPAR/2006/73986 |
| spellingShingle | Pascal Froment Philippe Touraine Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS) PPAR Research |
| title | Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS) |
| title_full | Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS) |
| title_fullStr | Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS) |
| title_full_unstemmed | Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS) |
| title_short | Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS) |
| title_sort | thiazolidinediones and fertility in polycystic ovary syndrome pcos |
| url | http://dx.doi.org/10.1155/PPAR/2006/73986 |
| work_keys_str_mv | AT pascalfroment thiazolidinedionesandfertilityinpolycysticovarysyndromepcos AT philippetouraine thiazolidinedionesandfertilityinpolycysticovarysyndromepcos |