Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response
Stereotactic body radiation therapy (SBRT) is a safe and effective treatment for oligometastatic gynecologic cancers. This report details the case of a 75-year-old woman with recurrent granulosa cell tumor of the left ovary. The patient was diagnosed with a peritoneal recurrence after her inhibin-B...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Gynecologic Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578925000335 |
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| author | Madeline Petty Vasanti Jhaveri Nicholas Taylor Benjamin Foster |
| author_facet | Madeline Petty Vasanti Jhaveri Nicholas Taylor Benjamin Foster |
| author_sort | Madeline Petty |
| collection | DOAJ |
| description | Stereotactic body radiation therapy (SBRT) is a safe and effective treatment for oligometastatic gynecologic cancers. This report details the case of a 75-year-old woman with recurrent granulosa cell tumor of the left ovary. The patient was diagnosed with a peritoneal recurrence after her inhibin-B level increased to 39.7 pg/mL, and a subsequent computed tomography (CT) scan of the abdomen and pelvis revealed an enlarging left-sided soft tissue mass in the sigmoid mesentery measuring 1.2 × 1.2 cm. She underwent SBRT, delivering 37.5 Gy in 5 fractions to the soft tissue mass. A CT scan post-treatment indicated the mass had decreased to 0.8 cm and that her inhibin B level decreased to < 7 pg/mL. This case highlights the effectiveness of SBRT in the management of oligometastatic ovarian cancer, achieving a marked radiographic and tumor marker response in patients with disease not amenable to surgical resection. |
| format | Article |
| id | doaj-art-19df656e12214db0879d290cf7d0f7a4 |
| institution | DOAJ |
| issn | 2352-5789 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj-art-19df656e12214db0879d290cf7d0f7a42025-08-20T03:10:31ZengElsevierGynecologic Oncology Reports2352-57892025-04-015810170810.1016/j.gore.2025.101708Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker responseMadeline Petty0Vasanti Jhaveri1Nicholas Taylor2Benjamin Foster3Lewis Katz School of Medicine, Temple University, 3500 N Broad St., Philadelphia, PA 19140, United StatesDepartment of Gynecology Oncology, St. Luke’s University Health Network, 701 Ostrum St., 5th Floor, Bethlehem, PA 18015, United States; Corresponding author.Department of Gynecology Oncology, St. Luke’s University Health Network, 701 Ostrum St., 5th Floor, Bethlehem, PA 18015, United StatesDepartment of Radiation Oncology, St. Luke’s University Health Network, 801 Ostrum St., Bethlehem, PA 18015, United StatesStereotactic body radiation therapy (SBRT) is a safe and effective treatment for oligometastatic gynecologic cancers. This report details the case of a 75-year-old woman with recurrent granulosa cell tumor of the left ovary. The patient was diagnosed with a peritoneal recurrence after her inhibin-B level increased to 39.7 pg/mL, and a subsequent computed tomography (CT) scan of the abdomen and pelvis revealed an enlarging left-sided soft tissue mass in the sigmoid mesentery measuring 1.2 × 1.2 cm. She underwent SBRT, delivering 37.5 Gy in 5 fractions to the soft tissue mass. A CT scan post-treatment indicated the mass had decreased to 0.8 cm and that her inhibin B level decreased to < 7 pg/mL. This case highlights the effectiveness of SBRT in the management of oligometastatic ovarian cancer, achieving a marked radiographic and tumor marker response in patients with disease not amenable to surgical resection.http://www.sciencedirect.com/science/article/pii/S2352578925000335Granulosa cell tumorStereotactic body radiation therapyInhibin B |
| spellingShingle | Madeline Petty Vasanti Jhaveri Nicholas Taylor Benjamin Foster Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response Gynecologic Oncology Reports Granulosa cell tumor Stereotactic body radiation therapy Inhibin B |
| title | Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response |
| title_full | Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response |
| title_fullStr | Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response |
| title_full_unstemmed | Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response |
| title_short | Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response |
| title_sort | oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response |
| topic | Granulosa cell tumor Stereotactic body radiation therapy Inhibin B |
| url | http://www.sciencedirect.com/science/article/pii/S2352578925000335 |
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